caa a22 4500 463191218 CHVBK 20180406164909.0 cr unu---uuuuu 170326e20070901xx s 000 0 eng 10.1007/s10973-006-7951-1 doi (NATIONALLICENCE)springer-10.1007/s10973-006-7951-1 Ternary solid-liquid equilibria for crystallization of pharmaceutical components [Elektronische Daten] [M. Hamedi, L. Pison, J. Grolier] Isothermal titration calorimetry (ITC) has been used to develop a method to construct the solid-liquid equilibrium line in ternary systems containing the solute to precipitate and an aqueous mixed solvent. The method consists in measuring the heat of dissolution of a solid component (the solute) during successive additions of the liquid solvent. The cumulated heat, resulting from the successive heat peaks obtained for the different injections of known volumes of solvent, plotted vs. the ratio of the numbers of moles n solvent /n solute is represented by two nearly straight lines. The intersection of the two lines gives the solubility limit and the corresponding enthalpy of dissolution of the solute in the solvent. Phase diagrams have been established at 303.15 K in binary mixed solvents ethanol-water over the whole concentration range for four components of pharmaceutical interest, namely: caffeine, nicotinamide, nicotinic acid and salicylic acid. Springer Science+Business Media LLC, 2007 caffeine nationallicence heat of dissolution nationallicence nicotinamide nationallicence nicotinic acid nationallicence salicylic acid nationallicence solid-liquid equilibrium nationallicence solubility nationallicence ternary systems nationallicence titration calorimetry nationallicence Hamedi M. Mechanical Engineering Department, K.N. Toosi University, Tehran, Iran aut Pison L. Laboratory of Thermodynamics of Solutions and Polymers, Blaise Pascal University, Aubière, France aut Grolier J. Laboratory of Thermodynamics of Solutions and Polymers, Blaise Pascal University, Aubière, France aut Journal of Thermal Analysis and Calorimetry Springer US; http://www.springer-ny.com 89/3(2007-09-01), 663-668 1388-6150 89:3<663 2007 89 10973 https://doi.org/10.1007/s10973-006-7951-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10973-006-7951-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hamedi M. Mechanical Engineering Department, K.N. Toosi University, Tehran, Iran aut NATIONALLICENCE 700 1- Pison L. Laboratory of Thermodynamics of Solutions and Polymers, Blaise Pascal University, Aubière, France aut NATIONALLICENCE 700 1- Grolier J. Laboratory of Thermodynamics of Solutions and Polymers, Blaise Pascal University, Aubière, France aut NATIONALLICENCE 773 0- Journal of Thermal Analysis and Calorimetry Springer US; http://www.springer-ny.com 89/3(2007-09-01), 663-668 1388-6150 89:3<663 2007 89 10973 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer