caa a22 4500 463191234 CHVBK 20180406164909.0 cr unu---uuuuu 170326e20070901xx s 000 0 eng 10.1007/s10973-006-7963-x doi (NATIONALLICENCE)springer-10.1007/s10973-006-7963-x Picker-Freyer Katharina Institute of Pharmaceutical Technology and Biopharmacy, Martin-Luther-University Halle-Wittenberg, Wolfgang-Langenbeck Str. 4, 06120, Halle/Saale, Germany aut An insight into the process of tablet formation of microcrystalline cellulose [Elektronische Daten] Structural changes on a nanoscale level [Katharina Picker-Freyer] The present paper aims to show whether the shrinking of the microcrystalline cellulose (MCC) tablets can be derived from underlying processes and whether these processes can be visualized on a nanoscale level. Tableting of MCC was performed on an instrumented eccentric tableting machine to a maximum relative density (ρrel,max) of 0.90 of the tablets. The apparent density of the tablets was analyzed by helium pycnometry after tableting. The breaking surface of a MCC tablet was analyzed directly after tableting continuously by video in an environmental scanning electron microscope (ESEM) at constant humidity. Further the breaking surface was analyzed by transmission electron microscopy (TEM) after freeze fracturing. The results show that firstly apparent density by helium pycnometry increases after tableting and that secondly inside the tablet the fiber strength decreased while also the gaps between the fibers increased as was visualized by ESEM. Further the results by TEM indicate that the decrease in fiber strength is caused by a parallel orientation of the MCC microcrystals which is induced by a mechanical activation due to tableting. In conclusion the measured shrinking MCC tablets after tableting is caused by processes on a nanoscale level. Springer Science+Business Media LLC, 2007 environmental scanning electron microscopy nationallicence microcrystalline cellulose nationallicence microcrystals nationallicence tableting nationallicence transmission electron microscopy nationallicence Journal of Thermal Analysis and Calorimetry Springer US; http://www.springer-ny.com 89/3(2007-09-01), 745-748 1388-6150 89:3<745 2007 89 10973 https://doi.org/10.1007/s10973-006-7963-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10973-006-7963-x text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Picker-Freyer Katharina Institute of Pharmaceutical Technology and Biopharmacy, Martin-Luther-University Halle-Wittenberg, Wolfgang-Langenbeck Str. 4, 06120, Halle/Saale, Germany aut NATIONALLICENCE 773 0- Journal of Thermal Analysis and Calorimetry Springer US; http://www.springer-ny.com 89/3(2007-09-01), 745-748 1388-6150 89:3<745 2007 89 10973 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer