caa a22 4500 463191315 CHVBK 20180406164910.0 cr unu---uuuuu 170326e20070901xx s 000 0 eng 10.1007/s10973-007-7874-5 doi (NATIONALLICENCE)springer-10.1007/s10973-007-7874-5 Thermal studies of pre-formulates of metronidazole obtained by spray drying technique [Elektronische Daten] [Antonilêni Medeiros, Ana Santos, F. de Souza, I. Júnior, J. Valdilânio, J. Procópio, D. de Santana, R. Macêdo] Compatibility studies between active drugs and excipients are substantial in the pharmaceutical technology. The objective of the present work was to develop pre-formulated mixtures of metronidazole (MT) obtained by spray drying (SPDR) and their thermoanalytical characterization. Dynamic and isothermal TG, conventional DSC and DSC coupled to a photovisual system were used. DSC experiments with both techniques confirmed the homogeneity of the conventional and pre-formulated mixtures. The TG data made possible the comparison the thermal stability of the different mixtures. Similar thermal stabilities were found of the conventional and pre-formulated mixtures, with slower particles sizes of MT. Springer Science+Business Media LLC, 2007 metronidazole nationallicence spray drying nationallicence thermal analysis nationallicence Medeiros Antonilêni Pharmaceutical Sciences Department, Federal University of Pernambuco — UFPE, Prof. Artur de Sá, s/n — University City Zip. 50, 740-521, Recife, PE, Brazil aut Santos Ana Pharmaceutical Sciences Department, Federal University of Pernambuco — UFPE, Prof. Artur de Sá, s/n — University City Zip. 50, 740-521, Recife, PE, Brazil aut de Souza F. Unified Laboratory of Medicine Development and Assay, LUDEM — Federal University of Paraíba — UFPB, Campus I Zip., 58059-900, João Pessoa, PB, Brazil aut Júnior I. Unified Laboratory of Medicine Development and Assay, LUDEM — Federal University of Paraíba — UFPB, Campus I Zip., 58059-900, João Pessoa, PB, Brazil aut Valdilânio J. aut Procópio J. Unified Laboratory of Medicine Development and Assay, LUDEM — Federal University of Paraíba — UFPB, Campus I Zip., 58059-900, João Pessoa, PB, Brazil aut de Santana D. Pharmaceutical Sciences Department, Federal University of Pernambuco — UFPE, Prof. Artur de Sá, s/n — University City Zip. 50, 740-521, Recife, PE, Brazil aut Macêdo R. Unified Laboratory of Medicine Development and Assay, LUDEM — Federal University of Paraíba — UFPB, Campus I Zip., 58059-900, João Pessoa, PB, Brazil aut Journal of Thermal Analysis and Calorimetry Springer US; http://www.springer-ny.com 89/3(2007-09-01), 775-781 1388-6150 89:3<775 2007 89 10973 https://doi.org/10.1007/s10973-007-7874-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10973-007-7874-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Medeiros Antonilêni Pharmaceutical Sciences Department, Federal University of Pernambuco — UFPE, Prof. Artur de Sá, s/n — University City Zip. 50, 740-521, Recife, PE, Brazil aut NATIONALLICENCE 700 1- Santos Ana Pharmaceutical Sciences Department, Federal University of Pernambuco — UFPE, Prof. Artur de Sá, s/n — University City Zip. 50, 740-521, Recife, PE, Brazil aut NATIONALLICENCE 700 1- de Souza F. Unified Laboratory of Medicine Development and Assay, LUDEM — Federal University of Paraíba — UFPB, Campus I Zip., 58059-900, João Pessoa, PB, Brazil aut NATIONALLICENCE 700 1- Júnior I. Unified Laboratory of Medicine Development and Assay, LUDEM — Federal University of Paraíba — UFPB, Campus I Zip., 58059-900, João Pessoa, PB, Brazil aut NATIONALLICENCE 700 1- Valdilânio J. aut NATIONALLICENCE 700 1- Procópio J. Unified Laboratory of Medicine Development and Assay, LUDEM — Federal University of Paraíba — UFPB, Campus I Zip., 58059-900, João Pessoa, PB, Brazil aut NATIONALLICENCE 700 1- de Santana D. Pharmaceutical Sciences Department, Federal University of Pernambuco — UFPE, Prof. Artur de Sá, s/n — University City Zip. 50, 740-521, Recife, PE, Brazil aut NATIONALLICENCE 700 1- Macêdo R. Unified Laboratory of Medicine Development and Assay, LUDEM — Federal University of Paraíba — UFPB, Campus I Zip., 58059-900, João Pessoa, PB, Brazil aut NATIONALLICENCE 773 0- Journal of Thermal Analysis and Calorimetry Springer US; http://www.springer-ny.com 89/3(2007-09-01), 775-781 1388-6150 89:3<775 2007 89 10973 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer