caa a22 4500 463191463 CHVBK 20180406164910.0 cr unu---uuuuu 170326e20070901xx s 000 0 eng 10.1007/s10973-006-7959-6 doi (NATIONALLICENCE)springer-10.1007/s10973-006-7959-6 Grinding of drugs with pharmaceutical excipients at cryogenic temperatures [Elektronische Daten] Part II. Cryogenic grinding of indomethacin-polyvinylpyrrolidone mixtures [T. Shakhtshneider, F. Danède, F. Capet, J. Willart, M. Descamps, L. Paccou, E. Surov, E. Boldyreva, V. Boldyrev] The effect of cryogenic grinding on the indomethacin (IMC) and its mixtures with polyvinylpyrrolidone (PVP) was studied by powder X-ray diffraction and differential scanning calorimetry. Cryoground mixtures were shown to form glass solutions. PVP inhibits the crystallization of IMC from the amorphous state: the crystallization temperature of IMC in the mixtures with PVP increases, and the amorphous state is preserved longer on storage. The mixtures were characterized by Raman spectroscopy. Dissolution of the IMC in the cryoground mixtures is higher as compared to the pure form, also after a prolonged storage. Springer Science+Business Media LLC, 2007 cryogrinding nationallicence crystallization nationallicence glass solution nationallicence glass transition nationallicence indomethacin nationallicence polyvinylpyrrolidone nationallicence Shakhtshneider T. Institute of Solid State Chemistry and Mechanochemistry SB RAS, 18 Kutateladze, 630128, Novosibirsk, Russia aut Danède F. Laboratoire de Dynamique et Structure des Matériaux Moléculaires, UMR CNRS 8024, ERT 1018, Université de Lille 1 Bât. P5, 59655, Villeneuve d'Ascq, France aut Capet F. Laboratoire de Dynamique et Structure des Matériaux Moléculaires, UMR CNRS 8024, ERT 1018, Université de Lille 1 Bât. P5, 59655, Villeneuve d'Ascq, France aut Willart J. Laboratoire de Dynamique et Structure des Matériaux Moléculaires, UMR CNRS 8024, ERT 1018, Université de Lille 1 Bât. P5, 59655, Villeneuve d'Ascq, France aut Descamps M. Laboratoire de Dynamique et Structure des Matériaux Moléculaires, UMR CNRS 8024, ERT 1018, Université de Lille 1 Bât. P5, 59655, Villeneuve d'Ascq, France aut Paccou L. Laboratoire de Dynamique et Structure des Matériaux Moléculaires, UMR CNRS 8024, ERT 1018, Université de Lille 1 Bât. P5, 59655, Villeneuve d'Ascq, France aut Surov E. Research and Education Centre ‘Molecular Design and Ecologically Safe Technologies' at Novosibirsk State University, 2 Pirogova, 630090, Novosibirsk, Russia aut Boldyreva E. Institute of Solid State Chemistry and Mechanochemistry SB RAS, 18 Kutateladze, 630128, Novosibirsk, Russia aut Boldyrev V. Institute of Solid State Chemistry and Mechanochemistry SB RAS, 18 Kutateladze, 630128, Novosibirsk, Russia aut Journal of Thermal Analysis and Calorimetry Springer US; http://www.springer-ny.com 89/3(2007-09-01), 709-715 1388-6150 89:3<709 2007 89 10973 https://doi.org/10.1007/s10973-006-7959-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10973-006-7959-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Shakhtshneider T. Institute of Solid State Chemistry and Mechanochemistry SB RAS, 18 Kutateladze, 630128, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Danède F. Laboratoire de Dynamique et Structure des Matériaux Moléculaires, UMR CNRS 8024, ERT 1018, Université de Lille 1 Bât. P5, 59655, Villeneuve d'Ascq, France aut NATIONALLICENCE 700 1- Capet F. Laboratoire de Dynamique et Structure des Matériaux Moléculaires, UMR CNRS 8024, ERT 1018, Université de Lille 1 Bât. P5, 59655, Villeneuve d'Ascq, France aut NATIONALLICENCE 700 1- Willart J. Laboratoire de Dynamique et Structure des Matériaux Moléculaires, UMR CNRS 8024, ERT 1018, Université de Lille 1 Bât. P5, 59655, Villeneuve d'Ascq, France aut NATIONALLICENCE 700 1- Descamps M. Laboratoire de Dynamique et Structure des Matériaux Moléculaires, UMR CNRS 8024, ERT 1018, Université de Lille 1 Bât. P5, 59655, Villeneuve d'Ascq, France aut NATIONALLICENCE 700 1- Paccou L. Laboratoire de Dynamique et Structure des Matériaux Moléculaires, UMR CNRS 8024, ERT 1018, Université de Lille 1 Bât. P5, 59655, Villeneuve d'Ascq, France aut NATIONALLICENCE 700 1- Surov E. Research and Education Centre ‘Molecular Design and Ecologically Safe Technologies' at Novosibirsk State University, 2 Pirogova, 630090, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Boldyreva E. Institute of Solid State Chemistry and Mechanochemistry SB RAS, 18 Kutateladze, 630128, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Boldyrev V. Institute of Solid State Chemistry and Mechanochemistry SB RAS, 18 Kutateladze, 630128, Novosibirsk, Russia aut NATIONALLICENCE 773 0- Journal of Thermal Analysis and Calorimetry Springer US; http://www.springer-ny.com 89/3(2007-09-01), 709-715 1388-6150 89:3<709 2007 89 10973 Metadata rights reserved Springer special CC-BY-NC licence nationallicence SWISSBIB 463191463 BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer