caa a22 4500 463191528 CHVBK 20180406164910.0 cr unu---uuuuu 170326e20070901xx s 000 0 eng 10.1007/s10973-006-7958-7 doi (NATIONALLICENCE)springer-10.1007/s10973-006-7958-7 Grinding of drugs with pharmaceutical excipients at cryogenic temperatures [Elektronische Daten] Part I. Cryogenic grinding of piroxicam-polyvinylpyrrolidone mixtures [T. Shakhtshneider, F. Danède, F. Capet, J. Willart, M. Descamps, S. Myz, E. Boldyreva, V. Boldyrev] The effect of cryogenic grinding on the piroxicam and its mixtures with polyvinylpyrrolidone (PVP) was studied by powder X-ray diffraction and differential scanning calorimetry (DSC). The crystallization of the amorphous piroxicam obtained during cryogrinding showed two events in a DSC curve (noticeable for pure piroxicam, and much more pronounced for the PVP-piroxicam mixtures). For the same measurement conditions, the intensity ratio of the peaks corresponding to the two events differed for the PVP-piroxicam mixtures of different drug-excipient ratios. The temperatures, at which these events were observed, increased with the increase in the PVP-concentration in the mixture. For the mixtures with a high relative content of PVP (≥60%), crystallization was not observed at all. Only one glass transition was revealed for the mixture containing 80% PVP suggesting that a molecular alloy was formed. Springer Science+Business Media LLC, 2007 cryogrinding nationallicence crystallization nationallicence glass transition nationallicence molecular alloy nationallicence piroxicam nationallicence polyvinylpyrrolidone nationallicence Shakhtshneider T. Institute of Solid State Chemistry and Mechanochemistry SB RAS, 18 Kutateladze, 630128, Novosibirsk, Russia aut Danède F. Laboratoire de Dynamique et Structure des Matériaux Moléculaires, UMR CNRS 8024, ERT 1018, Université de Lille 1 Bât. P5, 59655, Villeneuve d'Ascq, France aut Capet F. Laboratoire de Dynamique et Structure des Matériaux Moléculaires, UMR CNRS 8024, ERT 1018, Université de Lille 1 Bât. P5, 59655, Villeneuve d'Ascq, France aut Willart J. Laboratoire de Dynamique et Structure des Matériaux Moléculaires, UMR CNRS 8024, ERT 1018, Université de Lille 1 Bât. P5, 59655, Villeneuve d'Ascq, France aut Descamps M. Laboratoire de Dynamique et Structure des Matériaux Moléculaires, UMR CNRS 8024, ERT 1018, Université de Lille 1 Bât. P5, 59655, Villeneuve d'Ascq, France aut Myz S. Institute of Solid State Chemistry and Mechanochemistry SB RAS, 18 Kutateladze, 630128, Novosibirsk, Russia aut Boldyreva E. Institute of Solid State Chemistry and Mechanochemistry SB RAS, 18 Kutateladze, 630128, Novosibirsk, Russia aut Boldyrev V. Institute of Solid State Chemistry and Mechanochemistry SB RAS, 18 Kutateladze, 630128, Novosibirsk, Russia aut Journal of Thermal Analysis and Calorimetry Springer US; http://www.springer-ny.com 89/3(2007-09-01), 699-707 1388-6150 89:3<699 2007 89 10973 https://doi.org/10.1007/s10973-006-7958-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10973-006-7958-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Shakhtshneider T. Institute of Solid State Chemistry and Mechanochemistry SB RAS, 18 Kutateladze, 630128, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Danède F. Laboratoire de Dynamique et Structure des Matériaux Moléculaires, UMR CNRS 8024, ERT 1018, Université de Lille 1 Bât. P5, 59655, Villeneuve d'Ascq, France aut NATIONALLICENCE 700 1- Capet F. Laboratoire de Dynamique et Structure des Matériaux Moléculaires, UMR CNRS 8024, ERT 1018, Université de Lille 1 Bât. P5, 59655, Villeneuve d'Ascq, France aut NATIONALLICENCE 700 1- Willart J. Laboratoire de Dynamique et Structure des Matériaux Moléculaires, UMR CNRS 8024, ERT 1018, Université de Lille 1 Bât. P5, 59655, Villeneuve d'Ascq, France aut NATIONALLICENCE 700 1- Descamps M. Laboratoire de Dynamique et Structure des Matériaux Moléculaires, UMR CNRS 8024, ERT 1018, Université de Lille 1 Bât. P5, 59655, Villeneuve d'Ascq, France aut NATIONALLICENCE 700 1- Myz S. Institute of Solid State Chemistry and Mechanochemistry SB RAS, 18 Kutateladze, 630128, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Boldyreva E. Institute of Solid State Chemistry and Mechanochemistry SB RAS, 18 Kutateladze, 630128, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Boldyrev V. Institute of Solid State Chemistry and Mechanochemistry SB RAS, 18 Kutateladze, 630128, Novosibirsk, Russia aut NATIONALLICENCE 773 0- Journal of Thermal Analysis and Calorimetry Springer US; http://www.springer-ny.com 89/3(2007-09-01), 699-707 1388-6150 89:3<699 2007 89 10973 Metadata rights reserved Springer special CC-BY-NC licence nationallicence SWISSBIB 463191463 BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer