caa a22 4500 463191536 CHVBK 20180406164910.0 cr unu---uuuuu 170326e20070901xx s 000 0 eng 10.1007/s10973-006-7746-4 doi (NATIONALLICENCE)springer-10.1007/s10973-006-7746-4 Thermal stability and decomposition of pharmaceutical compounds [Elektronische Daten] [Elena Lizarraga, C. Zabaleta, J. Palop] Thermal analysis of fusion and decomposition processes were carried out on recently synthetized pharmaceutical compounds in order to establish thermal stability criteria. This study was carried out using thermogravimetry, TG, and differential scanning calorimetry, DSC. Degradation and fusion temperatures have been produced as thermal data with the aim of to study the thermal stability of the compounds. Relationship is found among stability and a series of effects of structure of the compounds. The compounds which present an amide functional group in the central molecule are more stable because they have a comparatively higher fusion and degradation temperature. In addition, the stability of this type of compounds depends on the position of the electrophilic substitution (in ortho, meta or para). Likewise, the groups linked to the aromatic ring with high electronic density give stability, and therefore are able to delocalize the charge in a greater spacial interval. Therefore, criteria for the selection of substituents have established that improve the stability of compounds Springer Science+Business Media LLC, 2007 calorimetry nationallicence degradation process nationallicence pharmaceuticals nationallicence structure nationallicence thermal analysis nationallicence thermal decomposition nationallicence thermal stability nationallicence thermogravimetric analysis nationallicence Lizarraga Elena Department of Organic and Pharmaceutical Chemistry, Faculty of Pharmacy, University of Navarra, Irunlarrea 1, 31008, Pamplona, Spain aut Zabaleta C. Department of Organic and Pharmaceutical Chemistry, Faculty of Pharmacy, University of Navarra, Irunlarrea 1, 31008, Pamplona, Spain aut Palop J. Department of Organic and Pharmaceutical Chemistry, Faculty of Pharmacy, University of Navarra, Irunlarrea 1, 31008, Pamplona, Spain aut Journal of Thermal Analysis and Calorimetry Springer US; http://www.springer-ny.com 89/3(2007-09-01), 783-792 1388-6150 89:3<783 2007 89 10973 https://doi.org/10.1007/s10973-006-7746-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10973-006-7746-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lizarraga Elena Department of Organic and Pharmaceutical Chemistry, Faculty of Pharmacy, University of Navarra, Irunlarrea 1, 31008, Pamplona, Spain aut NATIONALLICENCE 700 1- Zabaleta C. Department of Organic and Pharmaceutical Chemistry, Faculty of Pharmacy, University of Navarra, Irunlarrea 1, 31008, Pamplona, Spain aut NATIONALLICENCE 700 1- Palop J. Department of Organic and Pharmaceutical Chemistry, Faculty of Pharmacy, University of Navarra, Irunlarrea 1, 31008, Pamplona, Spain aut NATIONALLICENCE 773 0- Journal of Thermal Analysis and Calorimetry Springer US; http://www.springer-ny.com 89/3(2007-09-01), 783-792 1388-6150 89:3<783 2007 89 10973 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer