caa a22 4500 463191587 CHVBK 20180406164910.0 cr unu---uuuuu 170326e20070901xx s 000 0 eng 10.1007/s10973-006-7916-4 doi (NATIONALLICENCE)springer-10.1007/s10973-006-7916-4 The redox state influences the interaction of ubiquinones with phospholipid bilayers [Elektronische Daten] A DSC study [Y. Roche, P. Peretti, Sophie Bernard] Differential scanning calorimetry (DSC) has been used to study the interaction of ubiquinones (UQn) and their reduced forms, ubiquinols (UQnH2), with dipalmitoylphosphatidylcholine (DPPC) in multilamellar vesicles. The influence of the redox state has been investigated by comparing the effect of two ubiquinones with four (UQ4) and ten isoprene units (UQ10). In the presence of increasing amounts of UQ4 or UQ4H2, concomitant shift of the gel to liquid crystalline phase transition towards lower temperatures and vanishing of the pre-transition are observed. Short-chain homologues are thus inserted parallel to phospholipid chains, their quinone ring close to the polar headgroups of the DPPC, with a larger degree of penetration for the reduced form. In addition, broadening and skewing of the main transition peak claim for a lateral self-organization in highly concentrated regions of UQ4 and UQ4H2, with a redox state influence on the distribution in size and shape of lipid domains. The lipid thermotropic behavior is not affected by the presence of UQ10 which remain homogeneously dispersed within the midplane of the phospholipid bilayer, while effect of reduced UQ10H2 argues for a different organization. Springer Science+Business Media LLC, 2007 DSC nationallicence liposomes nationallicence phospholipid bilayer nationallicence ubiquinols nationallicence ubiquinones nationallicence Roche Y. Unité MéDIAN, UFR de Pharmacie, URCA-UMR CNRS 6142, 51 rue Cognacq-Jay, 51096, Reims Cedex, France aut Peretti P. Biomedical Research Center, Laboratoire de Neuro-Physique Cellulaire, Paris 5 — René Descartes University, EA 3817 45 rue des Saints-Pŕes, 75270, Paris Cedex 06, France aut Bernard Sophie Biomedical Research Center, Laboratoire de Neuro-Physique Cellulaire, Paris 5 — René Descartes University, EA 3817 45 rue des Saints-Pŕes, 75270, Paris Cedex 06, France aut Journal of Thermal Analysis and Calorimetry Springer US; http://www.springer-ny.com 89/3(2007-09-01), 867-873 1388-6150 89:3<867 2007 89 10973 https://doi.org/10.1007/s10973-006-7916-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10973-006-7916-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Roche Y. Unité MéDIAN, UFR de Pharmacie, URCA-UMR CNRS 6142, 51 rue Cognacq-Jay, 51096, Reims Cedex, France aut NATIONALLICENCE 700 1- Peretti P. Biomedical Research Center, Laboratoire de Neuro-Physique Cellulaire, Paris 5 — René Descartes University, EA 3817 45 rue des Saints-Pŕes, 75270, Paris Cedex 06, France aut NATIONALLICENCE 700 1- Bernard Sophie Biomedical Research Center, Laboratoire de Neuro-Physique Cellulaire, Paris 5 — René Descartes University, EA 3817 45 rue des Saints-Pŕes, 75270, Paris Cedex 06, France aut NATIONALLICENCE 773 0- Journal of Thermal Analysis and Calorimetry Springer US; http://www.springer-ny.com 89/3(2007-09-01), 867-873 1388-6150 89:3<867 2007 89 10973 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer