caa a22 4500 463191595 CHVBK 20180406164910.0 cr unu---uuuuu 170326e20070901xx s 000 0 eng 10.1007/s10973-006-8258-y doi (NATIONALLICENCE)springer-10.1007/s10973-006-8258-y Structural study of α-lactose monohydrate subjected to microwave irradiation [Elektronische Daten] [Anikó Szepes, Anke Fiebig, J. Ulrich, Piroska Szabó-Révész] The aim of this work was to investigate the influence of different levels of microwave irradiation on the structure and particle size characteristics of α-lactose monohydrate. The structural study of the samples was carried out by XRD, the presence of lactose polymorphs in the test samples was determined by DSC and the particle size distribution was measured by laser diffraction. The samples subjected to microwave irradiation retained their original X-ray patterns. No significant differences in thermal transition characteristics and particle size were observed. Hence, neither the occurrence of crystalline-amorphous transition resulted by microwave irradiation nor the presence of lactose polymorphs in the test samples can be assumed. The unmodified properties can be attributed to the fact that the water of crystallization is very difficult to remove from the crystal structure and is not free to move during microwave treatment, which results in stability to microwaves. Our results allow the conclusion that microwave processing of α-lactose monohydrate has no influence on further pharmaceutical technological properties, which are related to the structure and the particle size distribution of this substance. Springer Science+Business Media LLC, 2007 DSC nationallicence lactose nationallicence microwave nationallicence particle size nationallicence X-ray powder diffraction nationallicence Szepes Anikó Faculty of Pharmacy, Department of Pharmaceutical Technology, University of Szeged, Eötvös u. 6., 6720, Szeged, Hungary aut Fiebig Anke FB Ingenieurwissenschaften, Institut für Verfahrenstechnik/TVT, Martin-Luther-University Halle-Wittenberg, 06099, Halle/Saale, Germany aut Ulrich J. FB Ingenieurwissenschaften, Institut für Verfahrenstechnik/TVT, Martin-Luther-University Halle-Wittenberg, 06099, Halle/Saale, Germany aut Szabó-Révész Piroska Faculty of Pharmacy, Department of Pharmaceutical Technology, University of Szeged, Eötvös u. 6., 6720, Szeged, Hungary aut Journal of Thermal Analysis and Calorimetry Springer US; http://www.springer-ny.com 89/3(2007-09-01), 757-760 1388-6150 89:3<757 2007 89 10973 https://doi.org/10.1007/s10973-006-8258-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10973-006-8258-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Szepes Anikó Faculty of Pharmacy, Department of Pharmaceutical Technology, University of Szeged, Eötvös u. 6., 6720, Szeged, Hungary aut NATIONALLICENCE 700 1- Fiebig Anke FB Ingenieurwissenschaften, Institut für Verfahrenstechnik/TVT, Martin-Luther-University Halle-Wittenberg, 06099, Halle/Saale, Germany aut NATIONALLICENCE 700 1- Ulrich J. FB Ingenieurwissenschaften, Institut für Verfahrenstechnik/TVT, Martin-Luther-University Halle-Wittenberg, 06099, Halle/Saale, Germany aut NATIONALLICENCE 700 1- Szabó-Révész Piroska Faculty of Pharmacy, Department of Pharmaceutical Technology, University of Szeged, Eötvös u. 6., 6720, Szeged, Hungary aut NATIONALLICENCE 773 0- Journal of Thermal Analysis and Calorimetry Springer US; http://www.springer-ny.com 89/3(2007-09-01), 757-760 1388-6150 89:3<757 2007 89 10973 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer