caa a22 4500 463191609 CHVBK 20180406164910.0 cr unu---uuuuu 170326e20070901xx s 000 0 eng 10.1007/s10973-006-8206-x doi (NATIONALLICENCE)springer-10.1007/s10973-006-8206-x A thermodynamic study on the binding of magnesium with human growth hormone [Elektronische Daten] Consideration of the new extended coordination model solvation parameters [G. Rezaei Behbehani, A. Saboury] The thermodynamic parameters underlying the binding of Mg2+ to the hydrophobic core of human growth hormone, hGH, are determined using isothermal titration calorimetry. The interaction between Mg2+ and hGH (35 μM) was studied at 27°C in NaCl solution. A new solvation model was used to reproduce the enthalpies of Mg2+-hGH interaction over the whole Mg2+ concentrations. The solvation parameters recovered from the new salvation model, were correlated to the structural changes of hGH due to the metal ion interaction. Springer Science+Business Media LLC, 2007 human growth hormone nationallicence isothermal titration calorimetry nationallicence magnesium nationallicence solvation model nationallicence Rezaei Behbehani G. Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran aut Saboury A. Department of Chemistry, Imam Khomeini International University Qazvin, Qazvin, Iran aut Journal of Thermal Analysis and Calorimetry Springer US; http://www.springer-ny.com 89/3(2007-09-01), 857-861 1388-6150 89:3<857 2007 89 10973 https://doi.org/10.1007/s10973-006-8206-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10973-006-8206-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rezaei Behbehani G. Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran aut NATIONALLICENCE 700 1- Saboury A. Department of Chemistry, Imam Khomeini International University Qazvin, Qazvin, Iran aut NATIONALLICENCE 773 0- Journal of Thermal Analysis and Calorimetry Springer US; http://www.springer-ny.com 89/3(2007-09-01), 857-861 1388-6150 89:3<857 2007 89 10973 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer