caa a22 4500 463192621 CHVBK 20180406164913.0 cr unu---uuuuu 170326e20070301xx s 000 0 eng 10.1007/s10973-006-8193-y doi (NATIONALLICENCE)springer-10.1007/s10973-006-8193-y Thermaland kinetic study of statins [Elektronische Daten] Simvastatinand lovastatin [M. Souza, Marta Conceição, M. Silva, L. Soledade, A. Souza] Statins are a group of lipoproteins that are used in medicine to treat the high cholesterol level. The effectiveness of statins in reducing the cholesterol level is significant and in long time scale the reduction of the cholesterol level helps to avoid the incidence of degenerative diseases. Simvastatin and lovastatin are belonging to the ‘statins' family, one of the pharmacologic groups used in the control of dislipidemy. The objective of this work is the thermal stability and kinetic study of the active forms of simvastatin and lovastatin. Thermal data indicated that lovastatin and simvastatin are stable up to 190 and 170°C in air and up to 205 and 203°C in nitrogen, respectively. For melting temperatures DSC curves showed good correlation with the literature data. Comparing the activation energies of the statins at heating rate of 10°C min-1, lovastatin is more stable than simvastatin under the applied experimental conditions. Springer-Verlag, 2007 kinetic nationallicence statins nationallicence thermogravimetry nationallicence Souza M. Departamento de Química, Universidade Federal da Paraíba, CCEN, Campus I, CEP 58059-900, João Pessoa, PB, Brazil aut Conceição Marta Centro de Educação e Saúde, Universidade Federal de Campina Grande, Campus Cuité, Cuité, PB, Brazil aut Silva M. Departamento de Química, Universidade Federal da Paraíba, CCEN, Campus I, CEP 58059-900, João Pessoa, PB, Brazil aut Soledade L. Departamento de Química, Universidade Federal da Paraíba, CCEN, Campus I, CEP 58059-900, João Pessoa, PB, Brazil aut Souza A. Departamento de Química, Universidade Federal da Paraíba, CCEN, Campus I, CEP 58059-900, João Pessoa, PB, Brazil aut Journal of Thermal Analysis and Calorimetry Kluwer Academic Publishers 87/3(2007-03-01), 859-863 1388-6150 87:3<859 2007 87 10973 https://doi.org/10.1007/s10973-006-8193-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10973-006-8193-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Souza M. Departamento de Química, Universidade Federal da Paraíba, CCEN, Campus I, CEP 58059-900, João Pessoa, PB, Brazil aut NATIONALLICENCE 700 1- Conceição Marta Centro de Educação e Saúde, Universidade Federal de Campina Grande, Campus Cuité, Cuité, PB, Brazil aut NATIONALLICENCE 700 1- Silva M. Departamento de Química, Universidade Federal da Paraíba, CCEN, Campus I, CEP 58059-900, João Pessoa, PB, Brazil aut NATIONALLICENCE 700 1- Soledade L. Departamento de Química, Universidade Federal da Paraíba, CCEN, Campus I, CEP 58059-900, João Pessoa, PB, Brazil aut NATIONALLICENCE 700 1- Souza A. Departamento de Química, Universidade Federal da Paraíba, CCEN, Campus I, CEP 58059-900, João Pessoa, PB, Brazil aut NATIONALLICENCE 773 0- Journal of Thermal Analysis and Calorimetry Kluwer Academic Publishers 87/3(2007-03-01), 859-863 1388-6150 87:3<859 2007 87 10973 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer