caa a22 4500 463192826 CHVBK 20180406164914.0 cr unu---uuuuu 170326e20070301xx s 000 0 eng 10.1007/s10973-006-7684-1 doi (NATIONALLICENCE)springer-10.1007/s10973-006-7684-1 Drug-polymerinteraction in the all- trans retinoic acidrelease from chitosan microparticles [Elektronische Daten] [A. Lira, D. Nanclares, A. Neto, J. Marchetti] Chitosan microparticles were prepared with the purpose of incorporating all-trans retinoic acid (ATRA). Morphology, drug content, release behavior and the interaction between chitosan and ATRA were investigated. Chitosan microparticles presented irregular and rough surface and drug content of 47±3%. The results of DSC and IR spectroscopy demonstrated interaction between drug and polymer resulting from retinoate or retinoamide formation. The drug release study showed that approximately 90% of drug was not released from microparticles until the end of experiment (48 h). That release behavior was probably due to the strong drug-polymer interaction and the more compact network of microparticles formed. Springer-Verlag, 2007 all-trans retinoic acid nationallicence chitosan microparticles nationallicence drug-polymer interaction nationallicence Lira A. School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, São Paulo, Brazil aut Nanclares D. School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, São Paulo, Brazil aut Neto A. School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, São Paulo, Brazil aut Marchetti J. School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, São Paulo, Brazil aut Journal of Thermal Analysis and Calorimetry Kluwer Academic Publishers 87/3(2007-03-01), 899-903 1388-6150 87:3<899 2007 87 10973 https://doi.org/10.1007/s10973-006-7684-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10973-006-7684-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lira A. School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, São Paulo, Brazil aut NATIONALLICENCE 700 1- Nanclares D. School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, São Paulo, Brazil aut NATIONALLICENCE 700 1- Neto A. School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, São Paulo, Brazil aut NATIONALLICENCE 700 1- Marchetti J. School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, São Paulo, Brazil aut NATIONALLICENCE 773 0- Journal of Thermal Analysis and Calorimetry Kluwer Academic Publishers 87/3(2007-03-01), 899-903 1388-6150 87:3<899 2007 87 10973 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer