caa a22 4500 463192907 CHVBK 20180406164914.0 cr unu---uuuuu 170326e20070301xx s 000 0 eng 10.1007/s10973-006-7752-6 doi (NATIONALLICENCE)springer-10.1007/s10973-006-7752-6 Thermalbehavior of loratadine [Elektronische Daten] [L. Ramos, É. Cavalheiro] Simultaneous thermogravimetry (TG) and differential thermal analysis (DTA) techniques were used for the characterization the thermal degradation of loratadine, ethyl-4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidine)-1-piperidinecarboxylate. TG analysis revealed that the thermal decomposition occurs in one step in the 200-400°C range in nitrogen atmosphere. DTA and DSC curves showed that loratadine melts before the decomposition and the decomposition products are volatile in nitrogen. In air the decomposition follows very similar profile up to 300°C, but two exothermic events are observed in the 170-680°C temperature range. Flynn-Wall-Ozawa method was used for the solid-state kinetic analysis of loratadine thermal decomposition. The calculated activation energy (E a) was 91±1 kJ mol-1 for α between 0.02 and 0.2, where the mass loss is mainly due to the decomposition than to the evaporation of the decomposition products. Springer-Verlag, 2007 decomposition kinetic nationallicence DTA nationallicence loratadine nationallicence thermogravimetry nationallicence Ramos L. Departamento de Química e Física Molecular, Instituto de Química de São Carlos, Universidade de São Paulo, Av. do Trabalhador São-Carlense, 400 Centro, Caixa Postal 780, CEP: 13560-970, São Carlos, SP, Brazil aut Cavalheiro É. Departamento de Química e Física Molecular, Instituto de Química de São Carlos, Universidade de São Paulo, Av. do Trabalhador São-Carlense, 400 Centro, Caixa Postal 780, CEP: 13560-970, São Carlos, SP, Brazil aut Journal of Thermal Analysis and Calorimetry Kluwer Academic Publishers 87/3(2007-03-01), 831-834 1388-6150 87:3<831 2007 87 10973 https://doi.org/10.1007/s10973-006-7752-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10973-006-7752-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ramos L. Departamento de Química e Física Molecular, Instituto de Química de São Carlos, Universidade de São Paulo, Av. do Trabalhador São-Carlense, 400 Centro, Caixa Postal 780, CEP: 13560-970, São Carlos, SP, Brazil aut NATIONALLICENCE 700 1- Cavalheiro É. Departamento de Química e Física Molecular, Instituto de Química de São Carlos, Universidade de São Paulo, Av. do Trabalhador São-Carlense, 400 Centro, Caixa Postal 780, CEP: 13560-970, São Carlos, SP, Brazil aut NATIONALLICENCE 773 0- Journal of Thermal Analysis and Calorimetry Kluwer Academic Publishers 87/3(2007-03-01), 831-834 1388-6150 87:3<831 2007 87 10973 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer