caa a22 4500 46319294X CHVBK 20180406164914.0 cr unu---uuuuu 170326e20070301xx s 000 0 eng 10.1007/s10973-006-7741-9 doi (NATIONALLICENCE)springer-10.1007/s10973-006-7741-9 Developmentof thermogravimetric method to quantitative determination of mebendazole [Elektronische Daten] [Ana Gomes, Lidiane Correia, Mônica da Silva Simões, Rui Macêdo] The objective of this work was to develop and validate a fast and reproducible method able to determine the concentration of mebendazole in raw materials and tablets. The samples were analyzed by dynamic thermogravimetry, in the heating rates of 10, 20, 40, 60 and 80°C min-1, in the atmospheres of nitrogen and nitrogen with synthetic air. Obtained data were used in the equations of Antoine and Langmuir, with the purpose to get the pressure curves of those. Vapor pressure curves of drug and tablet of mebendazole were evaluated using the mathematical indexes of difference factor, f 1, and similarity factor, f 2, to compare its profiles. The data showed that there is no significant difference between the vapor pressure profiles of drug and tablet of mebendazole in both environmental conditions studied, what confirms that the process is really vaporization. The concentration of mebendazole was determined in the raw material and tablets with the drug. Springer-Verlag, 2007 equation of Antoine nationallicence equation of Langmuir nationallicence mebendazole nationallicence thermogravimetry nationallicence vapor pressure nationallicence Gomes Ana Federal University of Paraíba UFPB, Unified Development and Medicine Assays Laboratories LUDEM, Cidade Universitária, Campus I CCS, 58051-970, João Pessoa, Paraíba, Brazil aut Correia Lidiane Federal University of Paraíba UFPB, Unified Development and Medicine Assays Laboratories LUDEM, Cidade Universitária, Campus I CCS, 58051-970, João Pessoa, Paraíba, Brazil aut da Silva Simões Mônica Federal University of Paraíba UFPB, Unified Development and Medicine Assays Laboratories LUDEM, Cidade Universitária, Campus I CCS, 58051-970, João Pessoa, Paraíba, Brazil aut Macêdo Rui Federal University of Paraíba UFPB, Unified Development and Medicine Assays Laboratories LUDEM, Cidade Universitária, Campus I CCS, 58051-970, João Pessoa, Paraíba, Brazil aut Journal of Thermal Analysis and Calorimetry Kluwer Academic Publishers 87/3(2007-03-01), 919-925 1388-6150 87:3<919 2007 87 10973 https://doi.org/10.1007/s10973-006-7741-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10973-006-7741-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gomes Ana Federal University of Paraíba UFPB, Unified Development and Medicine Assays Laboratories LUDEM, Cidade Universitária, Campus I CCS, 58051-970, João Pessoa, Paraíba, Brazil aut NATIONALLICENCE 700 1- Correia Lidiane Federal University of Paraíba UFPB, Unified Development and Medicine Assays Laboratories LUDEM, Cidade Universitária, Campus I CCS, 58051-970, João Pessoa, Paraíba, Brazil aut NATIONALLICENCE 700 1- da Silva Simões Mônica Federal University of Paraíba UFPB, Unified Development and Medicine Assays Laboratories LUDEM, Cidade Universitária, Campus I CCS, 58051-970, João Pessoa, Paraíba, Brazil aut NATIONALLICENCE 700 1- Macêdo Rui Federal University of Paraíba UFPB, Unified Development and Medicine Assays Laboratories LUDEM, Cidade Universitária, Campus I CCS, 58051-970, João Pessoa, Paraíba, Brazil aut NATIONALLICENCE 773 0- Journal of Thermal Analysis and Calorimetry Kluwer Academic Publishers 87/3(2007-03-01), 919-925 1388-6150 87:3<919 2007 87 10973 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer