caa a22 4500 463193059 CHVBK 20180406164914.0 cr unu---uuuuu 170326e20070301xx s 000 0 eng 10.1007/s10973-006-7710-3 doi (NATIONALLICENCE)springer-10.1007/s10973-006-7710-3 Thermalanalysis applied in the osmotic tablets pre-formulation studies [Elektronische Daten] [M. Freitas, R. Alves, J. Matos, J. Marchetti1] Osmotically controlled and oral drug delivery systems utilize osmotic pressure for controlled delivery of active agent(s). Drug delivery from these systems, to a large extent, is independent of the physiological factors of the gastrointestinal tract and these systems can be utilized for systemic as well as targeted delivery of drugs. We apply the thermal methods and IR spectroscopy to study compatibility between atenolol and several excipients usually found in the osmotic systems formulations (Polyethylene oxide, MW 3350, 100000, 200000 and 5000000; HPMC K4000, magnesium stearate and cellulose acetate. Cellulose acetate, HPMC K4000 and magnesium stearate have essentially no interaction with atenolol otherwise all Polyethylene oxide excipients modifies significantly the drug melting point indicating some extend of interaction. Springer-Verlag, 2007 atenolol nationallicence compatibility nationallicence DSC nationallicence osmotic system nationallicence TG nationallicence Freitas M. Laboratório de Tecnologia Farmacêutica, Departament de Ciências Farmacêuticas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Av. do Café s/n, 14040-903, Ribeirão Preto, SP, Brazil aut Alves R. Departamento de Química, Universidade de São Paulo, Av. Lineu Prestes, 748, 05508-000, São Paulo, SP, Brazil aut Matos J. Departamento de Química, Universidade de São Paulo, Av. Lineu Prestes, 748, 05508-000, São Paulo, SP, Brazil aut Marchetti1 J. Laboratório de Tecnologia Farmacêutica, Departament de Ciências Farmacêuticas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Av. do Café s/n, 14040-903, Ribeirão Preto, SP, Brazil aut Journal of Thermal Analysis and Calorimetry Kluwer Academic Publishers 87/3(2007-03-01), 905-911 1388-6150 87:3<905 2007 87 10973 https://doi.org/10.1007/s10973-006-7710-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10973-006-7710-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Freitas M. Laboratório de Tecnologia Farmacêutica, Departament de Ciências Farmacêuticas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Av. do Café s/n, 14040-903, Ribeirão Preto, SP, Brazil aut NATIONALLICENCE 700 1- Alves R. Departamento de Química, Universidade de São Paulo, Av. Lineu Prestes, 748, 05508-000, São Paulo, SP, Brazil aut NATIONALLICENCE 700 1- Matos J. Departamento de Química, Universidade de São Paulo, Av. Lineu Prestes, 748, 05508-000, São Paulo, SP, Brazil aut NATIONALLICENCE 700 1- Marchetti1 J. Laboratório de Tecnologia Farmacêutica, Departament de Ciências Farmacêuticas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Av. do Café s/n, 14040-903, Ribeirão Preto, SP, Brazil aut NATIONALLICENCE 773 0- Journal of Thermal Analysis and Calorimetry Kluwer Academic Publishers 87/3(2007-03-01), 905-911 1388-6150 87:3<905 2007 87 10973 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer