caa a22 4500 463193652 CHVBK 20180406164916.0 cr unu---uuuuu 170326e20070101xx s 000 0 eng 10.1007/s10973-006-7707-y doi (NATIONALLICENCE)springer-10.1007/s10973-006-7707-y Comparisonof the fragility index of different eudragit polymers determined by activationenthalpies [Elektronische Daten] [Gabriella Csóka, A. Gelencsér, Dorottya Kiss, Eszter Pásztor, I. Klebovich, Romána Zelkó] The present study aimed to apply fragility index (m) of polymers in the determination of the optimal amount of plasticizer in polymer films. The fragility index of different Eudragit polymers (RS, RL, EPO) was assessed by differential scanning calorimerty (DSC), applying the Arrhenius connection (logq-1/T g). The fragility of Eudragit EPO films proved to be the highest, while in the case of RS and RL, the increase of the alkyl-chain length caused the increase of fragility. Studying the effect of plasticizer (triethyl citrate, TEC) on the m value of Eudragit RL and RS films, a near linear reduction of the fragility index could be observed between 5-30% TEC concentration, but above 30%, this value leveled out to constant. Springer-Verlag, 2006 activation enthalpy nationallicence EPO nationallicence Eudragit nationallicence fragility index nationallicence RL nationallicence RS nationallicence triethyl citrate nationallicence Csóka Gabriella Department of Pharmaceutics, Semmelweis University, Hőgyes E. Str. 7., 1092, Budapest, Hungary aut Gelencsér A. Department of Pharmaceutics, Semmelweis University, Hőgyes E. Str. 7., 1092, Budapest, Hungary aut Kiss Dorottya University Pharmacy Department of Pharmacy Administration, Semmelweis University, Hőgyes E. Str. 7-9., 1092, Budapest, Hungary aut Pásztor Eszter Department of Pharmaceutics, Semmelweis University, Hőgyes E. Str. 7., 1092, Budapest, Hungary aut Klebovich I. Department of Pharmaceutics, Semmelweis University, Hőgyes E. Str. 7., 1092, Budapest, Hungary aut Zelkó Romána University Pharmacy Department of Pharmacy Administration, Semmelweis University, Hőgyes E. Str. 7-9., 1092, Budapest, Hungary aut Journal of Thermal Analysis and Calorimetry Springer Netherlands 87/2(2007-01-01), 469-473 1388-6150 87:2<469 2007 87 10973 https://doi.org/10.1007/s10973-006-7707-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10973-006-7707-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Csóka Gabriella Department of Pharmaceutics, Semmelweis University, Hőgyes E. Str. 7., 1092, Budapest, Hungary aut NATIONALLICENCE 700 1- Gelencsér A. Department of Pharmaceutics, Semmelweis University, Hőgyes E. Str. 7., 1092, Budapest, Hungary aut NATIONALLICENCE 700 1- Kiss Dorottya University Pharmacy Department of Pharmacy Administration, Semmelweis University, Hőgyes E. Str. 7-9., 1092, Budapest, Hungary aut NATIONALLICENCE 700 1- Pásztor Eszter Department of Pharmaceutics, Semmelweis University, Hőgyes E. Str. 7., 1092, Budapest, Hungary aut NATIONALLICENCE 700 1- Klebovich I. Department of Pharmaceutics, Semmelweis University, Hőgyes E. Str. 7., 1092, Budapest, Hungary aut NATIONALLICENCE 700 1- Zelkó Romána University Pharmacy Department of Pharmacy Administration, Semmelweis University, Hőgyes E. Str. 7-9., 1092, Budapest, Hungary aut NATIONALLICENCE 773 0- Journal of Thermal Analysis and Calorimetry Springer Netherlands 87/2(2007-01-01), 469-473 1388-6150 87:2<469 2007 87 10973 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer