caa a22 4500 463193717 CHVBK 20180406164916.0 cr unu---uuuuu 170326e20071001xx s 000 0 eng 10.1007/s00420-007-0198-8 doi (NATIONALLICENCE)springer-10.1007/s00420-007-0198-8 Correlation between urinary methoxyacetic acid and exposure of ethylene glycol dimethyl ether in a lithium battery plant [Elektronische Daten] [Kozo Yokota, Hiroshi Ueno, Naoko Ikeda, Yasushi Johyama, Hiromi Michitsuji, Seiji Yamada] Objective: To examine the correlation between airborne ethylene glycol dimethyl ether (EGdiME) exposures and the urinary methoxyacetic acid (MAA) and to approach the issue of a permissible exposure limit for EGdiME. Methods: The survey was conducted on Thursday. Workers occupationally exposed to EGdiME, as well as nonexposed controls, were studied in combination with one of the authors, who was coincidentally exposed to EGdiME while carrying out the study. Air levels of EGdiME were determined by personal sampling on passive gas tubes. Urine was collected from nine control subjects and ten workers immediately before and after the shift, and from one of the authors at intervals during 12h. The analyses of EGdiME in air and MAA in urine were performed by gas chromatography with flame ionization detection. Results: The time-weighted average (TWA) air levels of EGdiME ranged from 0.7 to 10.5ppm during 8h work shifts. The urinary levels of MAA in one of the authors increased continuously during exposure and after the end of exposure. The levels of urinary MAA in the exposed workers were significantly higher than those in the control subjects. On the other hand, the postshift values were higher than the preshift values in the exposed workers, but the difference was not significant. A linear correlation was found between the TWA air levels of EGdiME and creatinine-adjusted MAA levels in urine collected at the end of the shift (r=0.933; P<0.0001). According to our equation, a linear extrapolation to the biological limit value recommended by Shih et al. (1999) of 40mg MAA/g crea indicated an average inhalation exposure to EGdiME over the workweek of 12ppm. Conclusions: These results indicate that the determination of MAA in urine is suitable for use in the biological monitoring of EGdiME exposure. Springer-Verlag, 2007 Biological monitoring nationallicence Ethylene glycol dimethyl ether nationallicence Glycol ethers nationallicence Methoxyacetic acid nationallicence Occupational exposure limit nationallicence Yokota Kozo Matsushita Science Center of Industrial Hygiene, 7-6 Tonoshima-cho, 571-0045, Kadoma, Osaka, Japan aut Ueno Hiroshi Matsushita Science Center of Industrial Hygiene, 7-6 Tonoshima-cho, 571-0045, Kadoma, Osaka, Japan aut Ikeda Naoko Matsushita Science Center of Industrial Hygiene, 7-6 Tonoshima-cho, 571-0045, Kadoma, Osaka, Japan aut Johyama Yasushi Matsushita Science Center of Industrial Hygiene, 7-6 Tonoshima-cho, 571-0045, Kadoma, Osaka, Japan aut Michitsuji Hiromi Matsushita Science Center of Industrial Hygiene, 7-6 Tonoshima-cho, 571-0045, Kadoma, Osaka, Japan aut Yamada Seiji Matsushita Science Center of Industrial Hygiene, 7-6 Tonoshima-cho, 571-0045, Kadoma, Osaka, Japan aut International Archives of Occupational and Environmental Health Springer-Verlag 81/1(2007-10-01), 123-126 0340-0131 81:1<123 2007 81 420 https://doi.org/10.1007/s00420-007-0198-8 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00420-007-0198-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yokota Kozo Matsushita Science Center of Industrial Hygiene, 7-6 Tonoshima-cho, 571-0045, Kadoma, Osaka, Japan aut NATIONALLICENCE 700 1- Ueno Hiroshi Matsushita Science Center of Industrial Hygiene, 7-6 Tonoshima-cho, 571-0045, Kadoma, Osaka, Japan aut NATIONALLICENCE 700 1- Ikeda Naoko Matsushita Science Center of Industrial Hygiene, 7-6 Tonoshima-cho, 571-0045, Kadoma, Osaka, Japan aut NATIONALLICENCE 700 1- Johyama Yasushi Matsushita Science Center of Industrial Hygiene, 7-6 Tonoshima-cho, 571-0045, Kadoma, Osaka, Japan aut NATIONALLICENCE 700 1- Michitsuji Hiromi Matsushita Science Center of Industrial Hygiene, 7-6 Tonoshima-cho, 571-0045, Kadoma, Osaka, Japan aut NATIONALLICENCE 700 1- Yamada Seiji Matsushita Science Center of Industrial Hygiene, 7-6 Tonoshima-cho, 571-0045, Kadoma, Osaka, Japan aut NATIONALLICENCE 773 0- International Archives of Occupational and Environmental Health Springer-Verlag 81/1(2007-10-01), 123-126 0340-0131 81:1<123 2007 81 420 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer