caa a22 4500 463193725 CHVBK 20180406164916.0 cr unu---uuuuu 170326e20071001xx s 000 0 eng 10.1007/s00420-007-0187-y doi (NATIONALLICENCE)springer-10.1007/s00420-007-0187-y A follow-up study of mortality among the arseniasis patients exposed to indoor combustion of high arsenic coal in Southwest Guizhou Autonomous Prefecture, China [Elektronische Daten] [Ji-gang Chen, Yu-gang Chen, Yun-shu Zhou, Guo-fang Lin, Xiu-jie Li, Chao-gang Jia, Wei-chao Guo, Hui Du, Hong-chao Lu, Hong Meng, Xin-jiang Zhang, Klaus Golka, Jian-hua Shen] Objective: This study was directed to ascertain the mortality of a group of arseniasis patients in an endemic rural township in Southwest China, where the residents were exposed for decades to indoor combustion of high arsenic coal. Methods: All the diagnosed arseniasis cases registered in 1991 were defined as the target population, which were assigned to three symptom subgroups by the severity of dermal lesions. The death cases were surveyed and checked. The follow-up period was 12.5years. The standardized mortality ratio (SMR) of all death causes combined, all cancers combined, and the cancers at every site were analyzed. The age standardized mortality rates (ASMRs) were calculated in three subgroups using the procedure of standardization. Results: One hundred and six death cases were recorded. Liver cirrhosis, non-melanotic skin cancer, lung and liver cancer were the four most prevalent death causes and referred to 70.8% (75/106) of the total death cases. The mortality of all death causes combined was not higher than that of the whole of China in 2001 (SMR=0.76, 95% CI 0.63-0.93). The crude mortality rate of non-melanotic skin cancer in males reached up to 128.66/105. SMRs of lung cancer and larynx cancer in males (SMRs 2.84 and 27.27, 95% CIs 1.51-4.86 and 5.61-79.62, respectively) significantly exceeded the levels for all male Chinese. ASMRs of all death causes combined, all cancers combined and non-melanotic skin cancer in males of the severe dermal symptoms subgroup were significantly higher than those in medium and/or mild dermal symptom subgroups. Conclusions: A significantly increased mortality due to lung cancer and non-melanotic skin cancer was confirmed, alike the situation in other arseniasis endemic areas in the world. No significant elevation of mortality due to liver cancer and bladder cancer was observed. Male arseniasis patients diagnosed with severe skin lesions face higher risks of malignancies and of non-melanotic skin cancer in particular in the following years. Springer-Verlag, 2007 Arseniasis nationallicence Mortality nationallicence Skin cancer nationallicence Lung cancer nationallicence Liver cirrhosis nationallicence Chen Ji-gang Municipal Center for Disease Prevention and Control of Shanghai, 200336, Shanghai, China aut Chen Yu-gang County Center for Disease Prevention and Control of Xinren, 562300, Xingren, Guizhou, China aut Zhou Yun-shu Prefecture Center for Disease Prevention and Control of Southwest Guizhou Buyi and Miao Ethnic Minority Autonomous Prefecture, 562400, Xingyi, Guizhou, China aut Lin Guo-fang Laboratory of Toxicology, Shanghai Institutes for Biological Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, 200032, Shanghai, China aut Li Xiu-jie Yuzhang Township Hospitals, 562308, Xingren, Guizhou, China aut Jia Chao-gang County Institute of Public Health Supervision of Xinren, 562300, Xingren, Guizhou, China aut Guo Wei-chao Laboratory of Toxicology, Shanghai Institutes for Biological Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, 200032, Shanghai, China aut Du Hui Prefecture Center for Disease Prevention and Control of Southwest Guizhou Buyi and Miao Ethnic Minority Autonomous Prefecture, 562400, Xingyi, Guizhou, China aut Lu Hong-chao Prefecture Center for Disease Prevention and Control of Southwest Guizhou Buyi and Miao Ethnic Minority Autonomous Prefecture, 562400, Xingyi, Guizhou, China aut Meng Hong Department of Health Statistics, Second Military Medical University, 200433, Shanghai, China aut Zhang Xin-jiang Division of Dermatology, Zunyi Medical College, Affiliated Hospital, 563003, Zunyi, Guizhou, China aut Golka Klaus Institute for Occupational Physiology at the University of Dortmund, 44139, Dortmund, Germany aut Shen Jian-hua Laboratory of Toxicology, Shanghai Institutes for Biological Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, 200032, Shanghai, China aut International Archives of Occupational and Environmental Health Springer-Verlag 81/1(2007-10-01), 9-17 0340-0131 81:1<9 2007 81 420 https://doi.org/10.1007/s00420-007-0187-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00420-007-0187-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chen Ji-gang Municipal Center for Disease Prevention and Control of Shanghai, 200336, Shanghai, China aut NATIONALLICENCE 700 1- Chen Yu-gang County Center for Disease Prevention and Control of Xinren, 562300, Xingren, Guizhou, China aut NATIONALLICENCE 700 1- Zhou Yun-shu Prefecture Center for Disease Prevention and Control of Southwest Guizhou Buyi and Miao Ethnic Minority Autonomous Prefecture, 562400, Xingyi, Guizhou, China aut NATIONALLICENCE 700 1- Lin Guo-fang Laboratory of Toxicology, Shanghai Institutes for Biological Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, 200032, Shanghai, China aut NATIONALLICENCE 700 1- Li Xiu-jie Yuzhang Township Hospitals, 562308, Xingren, Guizhou, China aut NATIONALLICENCE 700 1- Jia Chao-gang County Institute of Public Health Supervision of Xinren, 562300, Xingren, Guizhou, China aut NATIONALLICENCE 700 1- Guo Wei-chao Laboratory of Toxicology, Shanghai Institutes for Biological Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, 200032, Shanghai, China aut NATIONALLICENCE 700 1- Du Hui Prefecture Center for Disease Prevention and Control of Southwest Guizhou Buyi and Miao Ethnic Minority Autonomous Prefecture, 562400, Xingyi, Guizhou, China aut NATIONALLICENCE 700 1- Lu Hong-chao Prefecture Center for Disease Prevention and Control of Southwest Guizhou Buyi and Miao Ethnic Minority Autonomous Prefecture, 562400, Xingyi, Guizhou, China aut NATIONALLICENCE 700 1- Meng Hong Department of Health Statistics, Second Military Medical University, 200433, Shanghai, China aut NATIONALLICENCE 700 1- Zhang Xin-jiang Division of Dermatology, Zunyi Medical College, Affiliated Hospital, 563003, Zunyi, Guizhou, China aut NATIONALLICENCE 700 1- Golka Klaus Institute for Occupational Physiology at the University of Dortmund, 44139, Dortmund, Germany aut NATIONALLICENCE 700 1- Shen Jian-hua Laboratory of Toxicology, Shanghai Institutes for Biological Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, 200032, Shanghai, China aut NATIONALLICENCE 773 0- International Archives of Occupational and Environmental Health Springer-Verlag 81/1(2007-10-01), 9-17 0340-0131 81:1<9 2007 81 420 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer