caa a22 4500 463193822 CHVBK 20180406164916.0 cr unu---uuuuu 170326e20071101xx s 000 0 eng 10.1007/s00420-007-0200-5 doi (NATIONALLICENCE)springer-10.1007/s00420-007-0200-5 Re-assessment of the influence of polymorphisms of phase-II metabolic enzymes on renal cell cancer risk of trichloroethylene-exposed workers [Elektronische Daten] [Bernd Wiesenhütter, Silvia Selinski, Klaus Golka, Thomas Brüning, Hermann Bolt] Problem: Individual differences in susceptibility to trichloroethylene-induced nephrocarcinogenicity may be conferred by genetic polymorphisms of glutathione S-transferases (GST), because enzymes of this group are pivotal for the metabolic activation of trichloroethylene. Because of a potential involvement of N-acetylation in the detoxication of reactive trichloroethylene metabolite(s) to N-acetyl-cysteine derivatives, polymorphisms of the NAT2 gene may also be relevant. Methods: The primary collective used for a re-investigation of these questions was that of a hospital-based case-control study by Brüning et al. (Am J Ind Med 43:274-285, 2003) of 134 renal cell cancer cases (20 cases exposed to trichloroethylene) and 401 matched controls. Genetic polymorphisms of GSTT1, GSTM1, GSTP1 and NAT2 were studied. Additional control collectives of non-diseased persons were used for comparison of allele frequencies. Results: No genetic influences on the development of renal cancer due to trichloroethylene were apparent, related to the deletion polymorphisms of GSTT1 and GSTM1, as well as to the NAT2 rapid/slow acetylator states. However, renal cell cancer cases displayed a somewhat higher proportion of the homozygous GSTP1 313A wild type (GSTP1*A), although this was not statistically significant (χ2 test: P=0.1071, when using only the original controls of Brüning et al. (2003); P=0.0781 with inclusion of the additional controls). Conclusion: The re-investigation does not confirm the working hypothesis of an influence of the deletion polymorphisms of the glutathione S-transferases GSTT1 and GSTM1 on renal cell cancer development due to high occupational exposures to trichloroethylene. Springer-Verlag, 2007 Trichloroethylene nationallicence Renal cancer nationallicence Glutathione S -transferases nationallicence N -acetyl-transferases nationallicence GSTT1 nationallicence GSTM1 nationallicence GSTP1 nationallicence NAT2 nationallicence Wiesenhütter Bernd Institut für Arbeitsphysiologie an der Universität Dortmund (IfADo), Ardeystr. 67, 44139, Dortmund, Germany aut Selinski Silvia Institut für Arbeitsphysiologie an der Universität Dortmund (IfADo), Ardeystr. 67, 44139, Dortmund, Germany aut Golka Klaus Institut für Arbeitsphysiologie an der Universität Dortmund (IfADo), Ardeystr. 67, 44139, Dortmund, Germany aut Brüning Thomas Berufsgenossenschaftliches Forschungsinstitut für Arbeitsmedizin der Ruhr-Universität Bochum, Bürkle-de-la-Camp-Platz 1, 44789, Dortmund, Germany aut Bolt Hermann Institut für Arbeitsphysiologie an der Universität Dortmund (IfADo), Ardeystr. 67, 44139, Dortmund, Germany aut International Archives of Occupational and Environmental Health Springer-Verlag 81/2(2007-11-01), 247-251 0340-0131 81:2<247 2007 81 420 https://doi.org/10.1007/s00420-007-0200-5 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00420-007-0200-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wiesenhütter Bernd Institut für Arbeitsphysiologie an der Universität Dortmund (IfADo), Ardeystr. 67, 44139, Dortmund, Germany aut NATIONALLICENCE 700 1- Selinski Silvia Institut für Arbeitsphysiologie an der Universität Dortmund (IfADo), Ardeystr. 67, 44139, Dortmund, Germany aut NATIONALLICENCE 700 1- Golka Klaus Institut für Arbeitsphysiologie an der Universität Dortmund (IfADo), Ardeystr. 67, 44139, Dortmund, Germany aut NATIONALLICENCE 700 1- Brüning Thomas Berufsgenossenschaftliches Forschungsinstitut für Arbeitsmedizin der Ruhr-Universität Bochum, Bürkle-de-la-Camp-Platz 1, 44789, Dortmund, Germany aut NATIONALLICENCE 700 1- Bolt Hermann Institut für Arbeitsphysiologie an der Universität Dortmund (IfADo), Ardeystr. 67, 44139, Dortmund, Germany aut NATIONALLICENCE 773 0- International Archives of Occupational and Environmental Health Springer-Verlag 81/2(2007-11-01), 247-251 0340-0131 81:2<247 2007 81 420 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer