caa a22 4500 463193865 CHVBK 20180406164916.0 cr unu---uuuuu 170326e20071101xx s 000 0 eng 10.1007/s00420-007-0199-7 doi (NATIONALLICENCE)springer-10.1007/s00420-007-0199-7 Particulate air pollution and vascular reactivity: the bus stop study [Elektronische Daten] [Robert Dales, Ling Liu, Mietek Szyszkowicz, Mary Dalipaj, Jeff Willey, Ryan Kulka, Terrence Ruddy] Objective: Particulate air pollution is associated with cardiovascular morbidity but mechanisms are not well understood. We tested the effects on vascular reactivity of exposure to fine particulates matter mass (PM2.5), number of particles ≤1μm/m3 (PM1.0) and nitrogen dioxide concentration (NO2). Method: About 39 healthy volunteers sat outside for 2h at two different Ottawa bus stops. Flow-mediated vasodilation (FMD) of the brachial artery was then measured by ultrasound and expressed as: (maximum artery diameter after release of a blood pressure cuff inflated above systolic pressure—baseline resting diameter)/baseline resting diameter. Results: A 30μg/m3 increase in PM2.5 exposure corresponded to a 0.48% reduction in FMD, P=0.05 representing a 5% relative change in the maximum ability to dilate. Results were consistent between the two bus stops and not sensitive to type of analysis. No significant association was found between FMD and NO2, PM1.0 or traffic density. Conclusion: PM2.5 may reduce the capacity to vasodilate, a potential explanation for the documented association with cardiovascular morbidity. Springer-Verlag, 2007 Arteries nationallicence Endothelin nationallicence Epidemiology nationallicence Vasodilation nationallicence Pollution nationallicence PM2.5 : Particulates matter mass nationallicence PM1.0 : Number of particles ≤1μm/m3 nationallicence NO2 : Nitrogen dioxide concentration nationallicence COPD : Chronic obstructive pulmonary disease nationallicence TEI : Thermo Environmental Instruments Inc nationallicence Dales Robert Health Canada, A.L. 4602C, 400 Cooper Street, Room 2045, K1A 0K9, Ottawa, ON, Canada aut Liu Ling Air Health Effects Division, Health Canada, 269 Laurier Avenue, Room 3026, Postal Locator 4903B, K1A 0K9, Ottawa, ON, Canada aut Szyszkowicz Mietek Air Health Effects Division, Health Canada, 269 Laurier Avenue, Room 3-030, Postal Locator 4903B, K1A 0K9, Ottawa, ON, Canada aut Dalipaj Mary Nuclear Medicine, The Ottawa Hospital and Heart Institute, 40 Ruskin Street, K1Y 4W7, Ottawa, ON, Canada aut Willey Jeff Air Health Effects Division, Health Canada, 269 Laurier Avenue, Room 3-068, K1A 0K9, Ottawa, ON, Canada aut Kulka Ryan Air Health Effects Division, Health Canada, 269 Laurier Avenue West, 3rd Floor, K1A 0K9, Ottawa, ON, Canada aut Ruddy Terrence Nuclear Medicine, The Ottawa Hospital and University of Ottawa, 40 Ruskin Street, K1Y 4W7, Ottawa, ON, Canada aut International Archives of Occupational and Environmental Health Springer-Verlag 81/2(2007-11-01), 159-164 0340-0131 81:2<159 2007 81 420 https://doi.org/10.1007/s00420-007-0199-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00420-007-0199-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dales Robert Health Canada, A.L. 4602C, 400 Cooper Street, Room 2045, K1A 0K9, Ottawa, ON, Canada aut NATIONALLICENCE 700 1- Liu Ling Air Health Effects Division, Health Canada, 269 Laurier Avenue, Room 3026, Postal Locator 4903B, K1A 0K9, Ottawa, ON, Canada aut NATIONALLICENCE 700 1- Szyszkowicz Mietek Air Health Effects Division, Health Canada, 269 Laurier Avenue, Room 3-030, Postal Locator 4903B, K1A 0K9, Ottawa, ON, Canada aut NATIONALLICENCE 700 1- Dalipaj Mary Nuclear Medicine, The Ottawa Hospital and Heart Institute, 40 Ruskin Street, K1Y 4W7, Ottawa, ON, Canada aut NATIONALLICENCE 700 1- Willey Jeff Air Health Effects Division, Health Canada, 269 Laurier Avenue, Room 3-068, K1A 0K9, Ottawa, ON, Canada aut NATIONALLICENCE 700 1- Kulka Ryan Air Health Effects Division, Health Canada, 269 Laurier Avenue West, 3rd Floor, K1A 0K9, Ottawa, ON, Canada aut NATIONALLICENCE 700 1- Ruddy Terrence Nuclear Medicine, The Ottawa Hospital and University of Ottawa, 40 Ruskin Street, K1Y 4W7, Ottawa, ON, Canada aut NATIONALLICENCE 773 0- International Archives of Occupational and Environmental Health Springer-Verlag 81/2(2007-11-01), 159-164 0340-0131 81:2<159 2007 81 420 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer