caa a22 4500 463193881 CHVBK 20180406164916.0 cr unu---uuuuu 170326e20071101xx s 000 0 eng 10.1007/s00420-007-0202-3 doi (NATIONALLICENCE)springer-10.1007/s00420-007-0202-3 Performance of the beryllium blood lymphocyte proliferation test based on a long-term occupational surveillance program [Elektronische Daten] [Ellen Donovan, Marc Kolanz, David Galbraith, Pamela Chapman, Dennis Paustenbach] Objective: Data from surveys of the general workforce and new employees at a beryllium manufacturer were used to evaluate the performance of the beryllium blood lymphocyte proliferation test (BeBLPT). Methods: Over 10,000 results from nearly 2,400 participants collected over 12years were analyzed using consistent criteria to describe the performance characteristics of the BeBLPT. Results: Approximately 2% of new employees had at least one positive BeBLPT result at the time of hire, and approximately 1% of new employees with no known potential occupational or possible take-home exposures to beryllium were confirmed positive (two positive results) from the time of hire. Positive results were observed in some workers within weeks or months of initial exposure, and the median time to the first positive result in confirmed positive individuals was 5months. The prevalence of positive BeBLPT results was greatest during the first year of employment with an apparent peak in months 4-8. At least one negative or borderline/negative result was observed in 100% of new workers who underwent follow-up testing after they had been confirmed positive. There was no correlation between time of employment and an increasing prevalence of confirmed positive BeBLPT results in individual surveys; however, the cumulative incidence of confirmed positive results in subsets of workers that participated in multiple surveys increased over time. Conclusion: The detection of confirmed positive results in non-occupationally exposed persons, the apparent reversions of previously confirmed positive results, the identification of a positive BeBLPT peak prevalence period, and the variation in intra- and inter-laboratory test methods and interpretation should be considered when interpreting results from studies utilizing the BeBLPT, especially when considering worker-specific interventions. Additional research to refine the BeBLPT or develop a new test is needed to properly characterize the relationship between sensitization and subclinical or clinical indicators of chronic beryllium disease. Springer-Verlag, 2007 Beryllium nationallicence Lymphocyte nationallicence Surveillance nationallicence Hypersensitivity nationallicence Industrial hygiene nationallicence Donovan Ellen ChemRisk, Inc., 25 Jessie St. at Ecker Square, Suite 1800, 94105, San Francisco, CA, USA aut Kolanz Marc Brush Wellman Inc., 17876 St. Clair Ave, 44110, Cleveland, OH, USA aut Galbraith David ChemRisk, Inc., 25 Jessie St. at Ecker Square, Suite 1800, 94105, San Francisco, CA, USA aut Chapman Pamela ChemRisk, Inc., 25 Jessie St. at Ecker Square, Suite 1800, 94105, San Francisco, CA, USA aut Paustenbach Dennis ChemRisk, Inc., 25 Jessie St. at Ecker Square, Suite 1800, 94105, San Francisco, CA, USA aut International Archives of Occupational and Environmental Health Springer-Verlag 81/2(2007-11-01), 165-178 0340-0131 81:2<165 2007 81 420 https://doi.org/10.1007/s00420-007-0202-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00420-007-0202-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Donovan Ellen ChemRisk, Inc., 25 Jessie St. at Ecker Square, Suite 1800, 94105, San Francisco, CA, USA aut NATIONALLICENCE 700 1- Kolanz Marc Brush Wellman Inc., 17876 St. Clair Ave, 44110, Cleveland, OH, USA aut NATIONALLICENCE 700 1- Galbraith David ChemRisk, Inc., 25 Jessie St. at Ecker Square, Suite 1800, 94105, San Francisco, CA, USA aut NATIONALLICENCE 700 1- Chapman Pamela ChemRisk, Inc., 25 Jessie St. at Ecker Square, Suite 1800, 94105, San Francisco, CA, USA aut NATIONALLICENCE 700 1- Paustenbach Dennis ChemRisk, Inc., 25 Jessie St. at Ecker Square, Suite 1800, 94105, San Francisco, CA, USA aut NATIONALLICENCE 773 0- International Archives of Occupational and Environmental Health Springer-Verlag 81/2(2007-11-01), 165-178 0340-0131 81:2<165 2007 81 420 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer