caa a22 4500 463193946 CHVBK 20180406164917.0 cr unu---uuuuu 170326e20070501xx s 000 0 eng 10.1007/s00420-006-0153-0 doi (NATIONALLICENCE)springer-10.1007/s00420-006-0153-0 Risk factors associated with airway allergic diseases from exposure to laboratory animal allergens among veterinarians [Elektronische Daten] [Anna Krakowiak, Marta Wiszniewska, Patrycja Krawczyk, Bogdan Szulc, Tomasz Wittczak, Jolanta Walusiak, Cezary Pałczynski] Objectives: Investigate the risk factors for the development of occupational airway allergy (OAA) from exposure to laboratory animal allergens (LAA) among Polish veterinarians. Methods: Two hundred veterinarians responded to the questionnaire and were subjected to skin prick test (SPT) to common allergens and LAA (rat, mouse, hamster, guinea pig, rabbit). Evaluation of total serum IgE level and specific IgE against occupational allergens was performed. In addition, bronchial hyperreactivity (BHR) and peak expiratory flow rate (PEFR) were measured before and after specific challenge testing (SCT) only in the subjects with work-related symptoms suggestive of occupational asthma (OA). Results: The prevalence of asthmatic and ocular symptoms was statistically more prevalent in the group of veterinarians sensitised to LAA versus non-sensitised subjects. The most frequent occupational allergens of skin and serum reactivity were LAA (44.5 and 31.5%, respectively). In 41 (20.5%) and in 22 (11%) subjects out of 200 veterinarians, serum specific IgE to natural rubber latex (NRL) allergens and disinfectants was also found. Serum sensitisation to cat allergens and daily contact with laboratory animals (LA) increased the risk for developing isolated occupational rhinitis. Furthermore, working time of more than 10years and daily contact with LA were also significant risk factors for the development of OAA. Measuring PEFR and BHR before and after SCT is a useful method to confirm the presence of OA. Conclusions: Allergy to LAA is an important health problem among veterinary medicine practitioners in Poland. Springer-Verlag, 2006 Occupational allergy nationallicence Sensitisation nationallicence Veterinarians nationallicence OAA : Occupational airway allergy nationallicence LAA : Laboratory animal allergens nationallicence SPT : Skin prick test nationallicence BHR : Bronchial hyperreactivity nationallicence PEFR : Peak expiratory flow rate nationallicence SCT : Specific challenge testing nationallicence OA : Occupational asthma nationallicence NRL : Natural rubber latex nationallicence LA : Laboratory animals nationallicence Krakowiak Anna Department of Occupational Diseases, Nofer Institute of Occupational Medicine, 8 Teresy Street, 91-348, Lodz, Poland aut Wiszniewska Marta Department of Occupational Diseases, Nofer Institute of Occupational Medicine, 8 Teresy Street, 91-348, Lodz, Poland aut Krawczyk Patrycja Department of Occupational Diseases, Nofer Institute of Occupational Medicine, 8 Teresy Street, 91-348, Lodz, Poland aut Szulc Bogdan Department of Occupational Diseases, Nofer Institute of Occupational Medicine, 8 Teresy Street, 91-348, Lodz, Poland aut Wittczak Tomasz Department of Occupational Diseases, Nofer Institute of Occupational Medicine, 8 Teresy Street, 91-348, Lodz, Poland aut Walusiak Jolanta Department of Occupational Diseases, Nofer Institute of Occupational Medicine, 8 Teresy Street, 91-348, Lodz, Poland aut Pałczynski Cezary Department of Occupational Diseases, Nofer Institute of Occupational Medicine, 8 Teresy Street, 91-348, Lodz, Poland aut International Archives of Occupational and Environmental Health Springer-Verlag 80/6(2007-05-01), 465-475 0340-0131 80:6<465 2007 80 420 https://doi.org/10.1007/s00420-006-0153-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00420-006-0153-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Krakowiak Anna Department of Occupational Diseases, Nofer Institute of Occupational Medicine, 8 Teresy Street, 91-348, Lodz, Poland aut NATIONALLICENCE 700 1- Wiszniewska Marta Department of Occupational Diseases, Nofer Institute of Occupational Medicine, 8 Teresy Street, 91-348, Lodz, Poland aut NATIONALLICENCE 700 1- Krawczyk Patrycja Department of Occupational Diseases, Nofer Institute of Occupational Medicine, 8 Teresy Street, 91-348, Lodz, Poland aut NATIONALLICENCE 700 1- Szulc Bogdan Department of Occupational Diseases, Nofer Institute of Occupational Medicine, 8 Teresy Street, 91-348, Lodz, Poland aut NATIONALLICENCE 700 1- Wittczak Tomasz Department of Occupational Diseases, Nofer Institute of Occupational Medicine, 8 Teresy Street, 91-348, Lodz, Poland aut NATIONALLICENCE 700 1- Walusiak Jolanta Department of Occupational Diseases, Nofer Institute of Occupational Medicine, 8 Teresy Street, 91-348, Lodz, Poland aut NATIONALLICENCE 700 1- Pałczynski Cezary Department of Occupational Diseases, Nofer Institute of Occupational Medicine, 8 Teresy Street, 91-348, Lodz, Poland aut NATIONALLICENCE 773 0- International Archives of Occupational and Environmental Health Springer-Verlag 80/6(2007-05-01), 465-475 0340-0131 80:6<465 2007 80 420 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer