caa a22 4500 463194047 CHVBK 20180406164917.0 cr unu---uuuuu 170326e20070501xx s 000 0 eng 10.1007/s00420-006-0160-1 doi (NATIONALLICENCE)springer-10.1007/s00420-006-0160-1 Room size is the major determinant for tuberculin conversion in health care workers exposed to a multidrug-resistant tuberculosis patient [Elektronische Daten] [Alberto Franchi, Luca Richeldi, Giovanni Parrinello, Giuliano Franco] Objective: Transmission of Mycobacterium tuberculosis (MTB) to health care workers (HCWs) still represents a public health concern. A total of 71 obstetric workers underwent contact tracing after recent workplace exposure to a highly infectious multidrug-resistant tuberculosis patient [i.e., index case (IC)]. Aim of the study was to identify the main exposure predictors for the risk of conversion through evaluation of tuberculin screening results. Methods: HCWs were investigated by a questionnaire (community, occupational, IC exposure risk factors) and tuberculin skin test screening. Results: Conversion was detected in 5 (8%) of the 63 exposed workers and was not associated with either community or previous work-related risk factors. According to risk assessment, tuberculin conversion was related to neither amount time of exposure, workshifts, nor number of contacts. Conversely, an exposure to the IC in different hospital rooms was found significantly different among converters compared to non-converters (χ 2, P=0.004). In particular, conversion was associated with exposure in two (obstetric emergency room, ambulatory discharge) out of the nine contact environments. Tuberculin conversion rates were associated with the room cubations of the exposure environments (χ 2 for trend, P<0.01) and with worker age. In a logistic regression model adjusted for age, the lower room cubation was found the strongest predictor for tuberculin conversion (OR=2.46, P=0.02). Conclusion: The study shows that the factors affecting airborne mycobacterial dose (patient infectiousness, low sized confined rooms) were the major determinants for MTB transmission after a brief exposure to a highly infectious TB case. Springer-Verlag, 2006 Tuberculosis nationallicence Latent tuberculosis infection nationallicence Health care workers nationallicence Casual contacts nationallicence Hospital transmission nationallicence Occupational risk nationallicence Franchi Alberto Occupational Health Unit, Policlinico Hospital, 8th floor, room # 8.056, Via Largo del Pozzo 71, 41100, Modena, Italy aut Richeldi Luca Respiratory Disease, University of Modena and Reggio Emilia and Policlinico Hospital, Modena, Italy aut Parrinello Giovanni Section of Medical Statistics, University of Brescia, Brescia, Italy aut Franco Giuliano Occupational Health Unit, Policlinico Hospital, 8th floor, room # 8.056, Via Largo del Pozzo 71, 41100, Modena, Italy aut International Archives of Occupational and Environmental Health Springer-Verlag 80/6(2007-05-01), 533-538 0340-0131 80:6<533 2007 80 420 https://doi.org/10.1007/s00420-006-0160-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00420-006-0160-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Franchi Alberto Occupational Health Unit, Policlinico Hospital, 8th floor, room # 8.056, Via Largo del Pozzo 71, 41100, Modena, Italy aut NATIONALLICENCE 700 1- Richeldi Luca Respiratory Disease, University of Modena and Reggio Emilia and Policlinico Hospital, Modena, Italy aut NATIONALLICENCE 700 1- Parrinello Giovanni Section of Medical Statistics, University of Brescia, Brescia, Italy aut NATIONALLICENCE 700 1- Franco Giuliano Occupational Health Unit, Policlinico Hospital, 8th floor, room # 8.056, Via Largo del Pozzo 71, 41100, Modena, Italy aut NATIONALLICENCE 773 0- International Archives of Occupational and Environmental Health Springer-Verlag 80/6(2007-05-01), 533-538 0340-0131 80:6<533 2007 80 420 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer