caa a22 4500 463194055 CHVBK 20180406164917.0 cr unu---uuuuu 170326e20070701xx s 000 0 eng 10.1007/s00420-007-0176-1 doi (NATIONALLICENCE)springer-10.1007/s00420-007-0176-1 Elimination kinetics of metals after an accidental exposure to welding fumes [Elektronische Daten] [Karl Schaller, György Csanady, Johannes Filser, Barbara Jüngert, Hans Drexler] Objective: We had the opportunity to study the kinetics of metals in blood and urine samples of a flame-sprayer exposed to high accident-prone workplace exposure. We measured over 1year, the nickel, aluminium, and chromium concentrations in blood and urine specimens after exposure. On this basis, we evaluated the corresponding half-lives. Methods: Blood and urine sampling were carried out five times after accidental exposure over a period of 1year. The metals were analysed by graphite furnace atomic absorption spectrometry and Zeeman compensation with reliable methods. Either a mono-exponential or a bi-exponential function was fitted to the concentration-time courses of selected metals using weighted least squares non-linear regression analysis. The amount excreted in urine was calculated integrating the urinary decay curve and multiplying with the daily creatinine excretion. Results: The first examination was carried out 15days after exposure. The mean aluminium concentration in plasma was 8.2μg/l and in urine, 58.4μg/g creatinine. The mean nickel concentration in blood was 59.6μg/l and the excretion in urine 700μg/g creatinine. The mean chromium level in blood was 1.4μg/l in urine, 7.4μg/g creatinine. For the three elements, the metal concentrations in blood and urine exceeded the reference values at least in the initial phase. For nickel, the German biological threshold limit values (EKA) were exceeded. Conclusions: Aluminium showed a mono-exponential decay, whereas the elimination of chromium and nickel was biphasic in biological fluids of the accidentally exposed welder. The half-lives were as follows: for aluminium 140days (urine) and 160days (plasma); for chromium 40 and 730days (urine); for nickel 25 and 610days (urine) as well as 30 and 240days (blood). The renal clearance of aluminium and nickel was about 2l/h estimated for the last monitoring day. Springer-Verlag, 2007 Schaller Karl Institute and Out-Patient Clinic for Occupational, Social and Environmental Medicine, University of Erlangen-Nuernberg, Schillerstr. 25, 91054, Erlangen, Germany aut Csanady György Institute of Toxicology, GSF National Research Center for Environment and Health, 85764, Neuherberg, Germany aut Filser Johannes Institute of Toxicology, GSF National Research Center for Environment and Health, 85764, Neuherberg, Germany aut Jüngert Barbara Institute and Out-Patient Clinic for Occupational, Social and Environmental Medicine, University of Erlangen-Nuernberg, Schillerstr. 25, 91054, Erlangen, Germany aut Drexler Hans Institute and Out-Patient Clinic for Occupational, Social and Environmental Medicine, University of Erlangen-Nuernberg, Schillerstr. 25, 91054, Erlangen, Germany aut International Archives of Occupational and Environmental Health Springer-Verlag 80/7(2007-07-01), 635-641 0340-0131 80:7<635 2007 80 420 https://doi.org/10.1007/s00420-007-0176-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00420-007-0176-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Schaller Karl Institute and Out-Patient Clinic for Occupational, Social and Environmental Medicine, University of Erlangen-Nuernberg, Schillerstr. 25, 91054, Erlangen, Germany aut NATIONALLICENCE 700 1- Csanady György Institute of Toxicology, GSF National Research Center for Environment and Health, 85764, Neuherberg, Germany aut NATIONALLICENCE 700 1- Filser Johannes Institute of Toxicology, GSF National Research Center for Environment and Health, 85764, Neuherberg, Germany aut NATIONALLICENCE 700 1- Jüngert Barbara Institute and Out-Patient Clinic for Occupational, Social and Environmental Medicine, University of Erlangen-Nuernberg, Schillerstr. 25, 91054, Erlangen, Germany aut NATIONALLICENCE 700 1- Drexler Hans Institute and Out-Patient Clinic for Occupational, Social and Environmental Medicine, University of Erlangen-Nuernberg, Schillerstr. 25, 91054, Erlangen, Germany aut NATIONALLICENCE 773 0- International Archives of Occupational and Environmental Health Springer-Verlag 80/7(2007-07-01), 635-641 0340-0131 80:7<635 2007 80 420 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer