caa a22 4500 463194101 CHVBK 20180406164917.0 cr unu---uuuuu 170326e20070701xx s 000 0 eng 10.1007/s00420-006-0166-8 doi (NATIONALLICENCE)springer-10.1007/s00420-006-0166-8 Change in airway responsiveness over a workweek in organic waste loaders [Elektronische Daten] [Gea de Meer, Dick Heederik, Inge Wouters] Objective: Organic waste workers are exposed to high endotoxin levels that may result in respiratory health effects. This study describes changes in lung function and methacholine airway responsiveness over a workweek in household organic waste loaders. Methods: Assessment of lung function and methacholine airway responsiveness before and after a workweek in six organic waste loaders with and ten loaders without regular respiratory symptoms. Methacholine responsiveness was expressed as dose-response slope, i.e. % fall in FEV1 per mg methacholine compared to either the post-saline value (DRSsal), or the highest FEV1 (DRSmax). Results: Monday morning, FEV1 was similar in cases and controls. Over the workweek, FEV1 and MMEF decreased slightly in both cases and controls (P>0.10). In contrast, DRS increased in cases and decreased in control subjects (P<0.10). The difference in % change of DRS was statistically significant after adjustment for smoking and age. Conclusion: Our results suggest exaggeration of pre-existent airway inflammation during the workweek in organic waste loaders with regular respiratory symptoms. This needs confirmation in larger studies. Springer-Verlag, 2007 Organic waste nationallicence Methacholine challenge nationallicence Lung function nationallicence Pre/post workweek change nationallicence de Meer Gea Institute for Risk Assessment Sciences (IRAS), Environmental and Occupational Health, Utrecht University, Utrecht, The Netherlands aut Heederik Dick Institute for Risk Assessment Sciences (IRAS), Environmental and Occupational Health, Utrecht University, Utrecht, The Netherlands aut Wouters Inge Institute for Risk Assessment Sciences (IRAS), Environmental and Occupational Health, Utrecht University, Utrecht, The Netherlands aut International Archives of Occupational and Environmental Health Springer-Verlag 80/7(2007-07-01), 649-652 0340-0131 80:7<649 2007 80 420 https://doi.org/10.1007/s00420-006-0166-8 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00420-006-0166-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- de Meer Gea Institute for Risk Assessment Sciences (IRAS), Environmental and Occupational Health, Utrecht University, Utrecht, The Netherlands aut NATIONALLICENCE 700 1- Heederik Dick Institute for Risk Assessment Sciences (IRAS), Environmental and Occupational Health, Utrecht University, Utrecht, The Netherlands aut NATIONALLICENCE 700 1- Wouters Inge Institute for Risk Assessment Sciences (IRAS), Environmental and Occupational Health, Utrecht University, Utrecht, The Netherlands aut NATIONALLICENCE 773 0- International Archives of Occupational and Environmental Health Springer-Verlag 80/7(2007-07-01), 649-652 0340-0131 80:7<649 2007 80 420 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer