caa a22 4500 463194128 CHVBK 20180406164917.0 cr unu---uuuuu 170326e20070701xx s 000 0 eng 10.1007/s00420-006-0167-7 doi (NATIONALLICENCE)springer-10.1007/s00420-006-0167-7 Airflow limitation among workers in a labour-intensive coal mine in Tanzania [Elektronische Daten] [Simon Mamuya, Magne Bråtveit, Yohana Mashalla, Bente Moen] Objectives: To describe the relationship between cumulative respirable dust and quartz exposure and lung functioning among workers in a labour-intensive coal mine. Methods: The study population comprised 299 men working at a coal mine in Tanzania. Lung function was assessed using a Vitalograph alpha III spirometer in accordance with American Thoracic Society recommendations. Multiple linear regression models were developed to study the relationship between forced expiratory volume in 1s (FEV1), forced vital capacity (FVC) and FEV1/FVC and the cumulative dust or quartz exposure while adjusting for age, height and ever smoking. To evaluate trends for dose response, cumulative exposure concentrations for respirable dust and quartz were ranked and categorized in quartiles and the highest decile, with the first quartile as the reference group. Logistic regression models were used to determine odds ratios for FEV1/FVC<0.7 and FEV1%<80 for categories of cumulative dust or quartz exposure. Results: The prevalence of FEV1/FVC<0.7 among the workers was 17.3%. Workers in the development team (20.5%) had the highest prevalence of FEV1%<80%. The estimates of the effects of cumulative exposure on FEV1/FVC were −0.015% per mgyearsm-3 for respirable dust and -0.3% per mgyearsm-3 for respirable quartz. In logistic regression models, the odds ratios for airway limitation (FEV1/FVC<0.7) for the workers in the highest decile of cumulative dust and quartz exposure versus the referents were 4.36 (95% confidence interval: 1.06, 17.96) and 3.49 (0.92, 13.21), respectively. The upper 10% of workers by cumulative dust and quartz exposure also had higher odds ratios for predicted FEV1%<80% than the reference group odds ratio: 10.38 (1.38, 78.13) and 14.18 (1.72, 116.59), respectively. The results must be interpreted with caution due to a possible healthy worker effect and selection bias. Conclusion: Exposure to respirable coal mine dust was associated with airway limitation as measured by FEV1/FVC and predicted FEV1%. Springer-Verlag, 2007 Lung functioning tests nationallicence Coal mining nationallicence Dust nationallicence Quartz nationallicence Tanzania nationallicence Mamuya Simon Centre for International Health and Section for Occupational Medicine, Department of Public Health and Primary Health Care, University of Bergen, Kalfarveien 31, 5018, Bergen, Norway aut Bråtveit Magne Section for Occupational Medicine, Department of Public Health and Primary Health Care, University of Bergen, Kalfarveien 31, 5018, Bergen, Norway aut Mashalla Yohana Department of Physiology, Muhimbili University College of Health Sciences, P.O. Box 65001, Dar es Salaam, Tanzania aut Moen Bente Section for Occupational Medicine, Department of Public Health and Primary Health Care, University of Bergen, Kalfarveien 31, 5018, Bergen, Norway aut International Archives of Occupational and Environmental Health Springer-Verlag 80/7(2007-07-01), 567-575 0340-0131 80:7<567 2007 80 420 https://doi.org/10.1007/s00420-006-0167-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00420-006-0167-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mamuya Simon Centre for International Health and Section for Occupational Medicine, Department of Public Health and Primary Health Care, University of Bergen, Kalfarveien 31, 5018, Bergen, Norway aut NATIONALLICENCE 700 1- Bråtveit Magne Section for Occupational Medicine, Department of Public Health and Primary Health Care, University of Bergen, Kalfarveien 31, 5018, Bergen, Norway aut NATIONALLICENCE 700 1- Mashalla Yohana Department of Physiology, Muhimbili University College of Health Sciences, P.O. Box 65001, Dar es Salaam, Tanzania aut NATIONALLICENCE 700 1- Moen Bente Section for Occupational Medicine, Department of Public Health and Primary Health Care, University of Bergen, Kalfarveien 31, 5018, Bergen, Norway aut NATIONALLICENCE 773 0- International Archives of Occupational and Environmental Health Springer-Verlag 80/7(2007-07-01), 567-575 0340-0131 80:7<567 2007 80 420 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer