caa a22 4500 463194152 CHVBK 20180406164917.0 cr unu---uuuuu 170326e20070101xx s 000 0 eng 10.1007/s00420-006-0124-5 doi (NATIONALLICENCE)springer-10.1007/s00420-006-0124-5 Epidemiological and clinical investigations among employees in a former herbicide production process [Elektronische Daten] [Michael Nasterlack, Gerhard Hoffmann, Peter Messerer, Marvin Ott, Dirk Pallapies, Marcus Wrede, Andreas Zober] Objectives: To evaluate cancer incidence among employees assigned to a benzothiadiazin herbicide production facility between 1974 and 1984. Methods: Retrospective cohort study including 185 employees who had worked at least 3months in the facility. Cancers were identified by review of occupational medical records and interview. Standardized incidence ratios (SIRs) were computed using comparison data provided by the Saarland Cancer Registry. Separately, a medical examination including sonography of the prostate and thyroid and PSA testing was offered to all cohort members including retirees. Results: Between 1975 and 2002, 12 cancers were observed compared with 10.3 expected cases (SIR 1.2; 95% confidence interval 0.6-2.0). Cancer types (including two prostate, two colon and one rectal cancer) were distributed unremarkably with no clustering of rare cancers. Medical screening and subsequent specialist referrals led to detection of three prostate cancers among 117 participants in the screening examination. Conclusions: Because of the limited study power, a link between former employment in this herbicide production process and the occurrence of cancer cannot be ruled out with confidence, although the observed incidence and distribution of cancers in this small cohort may be consistent with that expected in the general population. Detection of three prostate cancers via the examination program is also consistent with the experience of cancer screening programs that include PSA testing. Enhanced screening for prostate cancer among men over age 50 can lead to detection of cancers at earlier ages than would otherwise be the case. This likelihood needs to be planned for and addressed in communications with the study population prior to undertaking such initiatives. Springer-Verlag, 2006 Herbicides nationallicence Cancer nationallicence Prostate cancer nationallicence Detection bias nationallicence Nasterlack Michael Occupational Medical and Health Protection Department, BASF AG, 67056, Ludwigshafen, Germany aut Hoffmann Gerhard Occupational Medical and Health Protection Department, BASF AG, 67056, Ludwigshafen, Germany aut Messerer Peter Occupational Medical and Health Protection Department, BASF AG, 67056, Ludwigshafen, Germany aut Ott Marvin Occupational Medical and Health Protection Department, BASF AG, 67056, Ludwigshafen, Germany aut Pallapies Dirk Occupational Medical and Health Protection Department, BASF AG, 67056, Ludwigshafen, Germany aut Wrede Marcus Occupational Medical and Health Protection Department, BASF AG, 67056, Ludwigshafen, Germany aut Zober Andreas Occupational Medical and Health Protection Department, BASF AG, 67056, Ludwigshafen, Germany aut International Archives of Occupational and Environmental Health Springer-Verlag 80/3(2007-01-01), 234-238 0340-0131 80:3<234 2007 80 420 https://doi.org/10.1007/s00420-006-0124-5 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00420-006-0124-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nasterlack Michael Occupational Medical and Health Protection Department, BASF AG, 67056, Ludwigshafen, Germany aut NATIONALLICENCE 700 1- Hoffmann Gerhard Occupational Medical and Health Protection Department, BASF AG, 67056, Ludwigshafen, Germany aut NATIONALLICENCE 700 1- Messerer Peter Occupational Medical and Health Protection Department, BASF AG, 67056, Ludwigshafen, Germany aut NATIONALLICENCE 700 1- Ott Marvin Occupational Medical and Health Protection Department, BASF AG, 67056, Ludwigshafen, Germany aut NATIONALLICENCE 700 1- Pallapies Dirk Occupational Medical and Health Protection Department, BASF AG, 67056, Ludwigshafen, Germany aut NATIONALLICENCE 700 1- Wrede Marcus Occupational Medical and Health Protection Department, BASF AG, 67056, Ludwigshafen, Germany aut NATIONALLICENCE 700 1- Zober Andreas Occupational Medical and Health Protection Department, BASF AG, 67056, Ludwigshafen, Germany aut NATIONALLICENCE 773 0- International Archives of Occupational and Environmental Health Springer-Verlag 80/3(2007-01-01), 234-238 0340-0131 80:3<234 2007 80 420 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer