caa a22 4500 463194179 CHVBK 20180406164917.0 cr unu---uuuuu 170326e20070101xx s 000 0 eng 10.1007/s00420-006-0117-4 doi (NATIONALLICENCE)springer-10.1007/s00420-006-0117-4 Changes in tubular dysfunction marker levels in parallel with the levels of copper, rather than cadmium, in urine of middle-aged women in non-polluted areas [Elektronische Daten] [Masayuki Ikeda, Fumiko Ohashi, Yoshinari Fukui, Shiro Takada, Jiro Moriguchi, Takafumi Ezaki] Objective: This study was initiated to investigate if and to what extent the elevations in urinary α1- and β2-microglobulins (α1-MG and β2-MG, respectively) are specific to Cd nephro-toxicity. Methods: Stored urine samples, collected from 1,000 adult women in 11 prefectures all over Japan, were analysed for eight elements (Ca, Cd, Co, Cu, Mg, Mn, Ni and Zn), α1-MG, β2-MG, creatinine (CR) and specific gravity (SG); the data were cited from previous publications. The levels of eight elements and two MGs were expressed as observed and after correction for CR or SG (1.016). Age, CR and SG distributed normally, whereas two MGs and eight elements distributed log-normally. The 1,000 cases were classified into quartiles (i.e., 250 cases/group) of the lowest to the highest values (Groups A to D) for each element. Results: α1-MG and β2-MG increased as a function of Ca, Cd and Cu when corrected for CR, and the two MGs increased in parallel only with Cd and Cu after SG correction. Prevalence of α1-MG-uria (cut-off values; 5.3 and 6.5mg/g cr or l) and β2-MG-uria (cut-off values; 300 and 400μg/g cr or l) was elevated with increasing Ca, Cd and Cu when corrected for CR, but only with Cd and Cu when corrected for SG. Multiple regression analysis of 353 cases of 50-59year-old women with the eight element levels as independent variables and one of the two MGs as a dependent variable showed that Cu was the most influential element, and both Cd and Zn were less influential. Conclusions: Urinary levels of α1-MG and β2-MG among women with no environmental Cd exposure correlated more closely with Cu levels than Cd levels in urine. The observation suggests that sub-clinical elevation in α1-MG and β2-MG is not always attributable to nephro-toxicity of Cd, and that consideration on possible effects of other elements such as Cu is necessary. Springer-Verlag, 2006 Calcium nationallicence Cadmium nationallicence Copper nationallicence α1-Microglobulin nationallicence β2-Microglobulin nationallicence Women nationallicence Zinc nationallicence Ikeda Masayuki Kyoto Industrial Health Association, 67 Nishinokyo-Kitatsuboicho, Nakagyo-ku, 604-8472, Kyoto, Japan aut Ohashi Fumiko Kyoto Industrial Health Association, 67 Nishinokyo-Kitatsuboicho, Nakagyo-ku, 604-8472, Kyoto, Japan aut Fukui Yoshinari Kyoto Industrial Health Association, 67 Nishinokyo-Kitatsuboicho, Nakagyo-ku, 604-8472, Kyoto, Japan aut Takada Shiro Kyoto Industrial Health Association, 67 Nishinokyo-Kitatsuboicho, Nakagyo-ku, 604-8472, Kyoto, Japan aut Moriguchi Jiro Kyoto Industrial Health Association (Uji Office), 1-7, Hironocho-Narita, Uji City, 611-0031, Kyoto, Japan aut Ezaki Takafumi Kyoto Industrial Health Association, 67 Nishinokyo-Kitatsuboicho, Nakagyo-ku, 604-8472, Kyoto, Japan aut International Archives of Occupational and Environmental Health Springer-Verlag 80/3(2007-01-01), 171-183 0340-0131 80:3<171 2007 80 420 https://doi.org/10.1007/s00420-006-0117-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00420-006-0117-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ikeda Masayuki Kyoto Industrial Health Association, 67 Nishinokyo-Kitatsuboicho, Nakagyo-ku, 604-8472, Kyoto, Japan aut NATIONALLICENCE 700 1- Ohashi Fumiko Kyoto Industrial Health Association, 67 Nishinokyo-Kitatsuboicho, Nakagyo-ku, 604-8472, Kyoto, Japan aut NATIONALLICENCE 700 1- Fukui Yoshinari Kyoto Industrial Health Association, 67 Nishinokyo-Kitatsuboicho, Nakagyo-ku, 604-8472, Kyoto, Japan aut NATIONALLICENCE 700 1- Takada Shiro Kyoto Industrial Health Association, 67 Nishinokyo-Kitatsuboicho, Nakagyo-ku, 604-8472, Kyoto, Japan aut NATIONALLICENCE 700 1- Moriguchi Jiro Kyoto Industrial Health Association (Uji Office), 1-7, Hironocho-Narita, Uji City, 611-0031, Kyoto, Japan aut NATIONALLICENCE 700 1- Ezaki Takafumi Kyoto Industrial Health Association, 67 Nishinokyo-Kitatsuboicho, Nakagyo-ku, 604-8472, Kyoto, Japan aut NATIONALLICENCE 773 0- International Archives of Occupational and Environmental Health Springer-Verlag 80/3(2007-01-01), 171-183 0340-0131 80:3<171 2007 80 420 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer