caa a22 4500 463194209 CHVBK 20180406164917.0 cr unu---uuuuu 170326e20070101xx s 000 0 eng 10.1007/s00420-006-0119-2 doi (NATIONALLICENCE)springer-10.1007/s00420-006-0119-2 Individual lifetime exposure to inorganic arsenic using a space-time information system [Elektronische Daten] [Jaymie Meliker, Melissa Slotnick, Gillian AvRuskin, Andrew Kaufmann, Stacey Fedewa, Pierre Goovaerts, Geoffrey Jacquez, Jerome Nriagu] Objectives: A space-time information system (STIS) based method is introduced for calculating individual-level estimates of inorganic arsenic exposure over the adult life-course. STIS enables visualization and analysis of space-time data, overcoming some of the constraints inherent to spatial-only Geographic Information System software. The power of this new methodology is demonstrated using data from southeastern Michigan where 8% of the population is exposed to arsenic >10μg/l (the World Health Organization guideline) in home drinking water. Methods: Participants (N=440) are members of a control group in a population-based bladder cancer case-control study in southeastern Michigan and were recruited by phone using random digit dialing. Water samples were collected and analyzed for arsenic at current residence and participants were required to answer questions concerning lifetime mobility history and dietary habits. Inorganic arsenic concentrations were estimated at past residences and workplaces, and in select foods. Fluid and food consumption data were integrated with mobility histories and arsenic concentrations to calculate continuous estimates of inorganic arsenic intake over the adult life-course. Results: Estimates of continuous arsenic exposure are displayed, making use of both participant age and calendar year as measures of time. Results illustrate considerable temporal variability in individual-level exposure, with 26% of the participants experiencing a change in drinking water arsenic concentration of at least ±10μg/l over their adult lives. The average cumulative intake over the adult life-course ranges from 2.53×104-1.30×105μg, depending on the selected exposure metric. Conclusions: The STIS-based exposure assessment method allows for flexible inclusion of different parameters or alternative formulations of those parameters, thus enabling the calculation of different exposure metrics. This flexibility is particularly useful when additional exposure routes are considered, input datasets are updated, or when a scientific consensus does not exist regarding the proper formulation of the exposure metric. These results demonstrate the potential of STIS as a useful tool for calculating continuous estimates of adult lifetime exposure to arsenic or other environmental contaminants for application in exposure and risk assessment. Springer-Verlag, 2006 Drinking water nationallicence GIS nationallicence STIS nationallicence Exposure assessment nationallicence Environmental epidemiology nationallicence Meliker Jaymie BioMedware, Inc., 516 N. State St, 48104, Ann Arbor, MI, USA aut Slotnick Melissa Department of Environmental Health Sciences, School of Public Health, University of Michigan, 109 S. Observatory St., SPH Bldg 1, 48109-2029, Ann Arbor, MI, USA aut AvRuskin Gillian BioMedware, Inc., 516 N. State St, 48104, Ann Arbor, MI, USA aut Kaufmann Andrew BioMedware, Inc., 516 N. State St, 48104, Ann Arbor, MI, USA aut Fedewa Stacey Department of Environmental Health Sciences, School of Public Health, University of Michigan, 109 S. Observatory St., SPH Bldg 1, 48109-2029, Ann Arbor, MI, USA aut Goovaerts Pierre BioMedware, Inc., 516 N. State St, 48104, Ann Arbor, MI, USA aut Jacquez Geoffrey BioMedware, Inc., 516 N. State St, 48104, Ann Arbor, MI, USA aut Nriagu Jerome Department of Environmental Health Sciences, School of Public Health, University of Michigan, 109 S. Observatory St., SPH Bldg 1, 48109-2029, Ann Arbor, MI, USA aut International Archives of Occupational and Environmental Health Springer-Verlag 80/3(2007-01-01), 184-197 0340-0131 80:3<184 2007 80 420 https://doi.org/10.1007/s00420-006-0119-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00420-006-0119-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Meliker Jaymie BioMedware, Inc., 516 N. State St, 48104, Ann Arbor, MI, USA aut NATIONALLICENCE 700 1- Slotnick Melissa Department of Environmental Health Sciences, School of Public Health, University of Michigan, 109 S. Observatory St., SPH Bldg 1, 48109-2029, Ann Arbor, MI, USA aut NATIONALLICENCE 700 1- AvRuskin Gillian BioMedware, Inc., 516 N. State St, 48104, Ann Arbor, MI, USA aut NATIONALLICENCE 700 1- Kaufmann Andrew BioMedware, Inc., 516 N. State St, 48104, Ann Arbor, MI, USA aut NATIONALLICENCE 700 1- Fedewa Stacey Department of Environmental Health Sciences, School of Public Health, University of Michigan, 109 S. Observatory St., SPH Bldg 1, 48109-2029, Ann Arbor, MI, USA aut NATIONALLICENCE 700 1- Goovaerts Pierre BioMedware, Inc., 516 N. State St, 48104, Ann Arbor, MI, USA aut NATIONALLICENCE 700 1- Jacquez Geoffrey BioMedware, Inc., 516 N. State St, 48104, Ann Arbor, MI, USA aut NATIONALLICENCE 700 1- Nriagu Jerome Department of Environmental Health Sciences, School of Public Health, University of Michigan, 109 S. Observatory St., SPH Bldg 1, 48109-2029, Ann Arbor, MI, USA aut NATIONALLICENCE 773 0- International Archives of Occupational and Environmental Health Springer-Verlag 80/3(2007-01-01), 184-197 0340-0131 80:3<184 2007 80 420 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer