caa a22 4500 463194306 CHVBK 20180406164918.0 cr unu---uuuuu 170326e20070201xx s 000 0 eng 10.1007/s00420-006-0136-1 doi (NATIONALLICENCE)springer-10.1007/s00420-006-0136-1 Occurrence of perfluorinated substances in an adult German population in southern Bavaria [Elektronische Daten] [H. Fromme, O. Midasch, D. Twardella, J. Angerer, S. Boehmer, B. Liebl] Objectives: Perfluorinated compounds (PFCs) are a large group of chemicals produced for several decades and widely used for many industrial and consumer applications. Because of their global occurrence in different environmental media, their persistence, and their potential to bioaccumulate in organisms they are of toxicological and public concern. Methods: In the present study, the internal exposure to perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) in 356 human plasma samples collected from an adult population in Germany in 2005 is quantified. Results: We were able to detect the target analytes in all plasma samples and observed a significant correlation between the PFOS and PFOA concentrations. In female participants, the levels of PFOS and PFOA ranged between 2.5-30.7 (median: 10.9μg/l) and 1.5-16.2μg/l (median: 4.8μg/l), respectively. In males we observed concentrations from 2.1 to 55.0μg/l (median: 13.7μg/l) for PFOS and from 0.5 to 19.1μg/l (median: 5.7μg/l) for PFOA. A significant correlation between both PFOS and PFOA concentrations and gender was observed. We also found increased levels of the PFCs with increasing age of the participants, but this association reached statistical significance among females only. Conclusions: Our data agree well with results of other recent studies in Europe and suggest that the current exposure of the adult German population is lower than the exposure of the US and Canadian population. The sources of human exposure are currently not well understood. Toxicological implications are restricted to animal studies and occupational investigations not adequate for quantitative risk assessment in humans. Overall, more scientific research is necessary to characterize the body burden of PFCs (especially for relevant subsets of the population) and the main sources and routes, which are responsible for human exposure and possible health implications of these compounds. Springer-Verlag, 2006 PFOS nationallicence PFOA nationallicence PFC nationallicence Blood nationallicence Biomarkers nationallicence Human nationallicence Fromme H. Bavarian Health and Food Safety Authority, Department of Environmental Health, Veterinaerstrasse 2, 85764, Oberschleissheim, Germany aut Midasch O. Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen-Nuremberg, Schillerstrasse 25/29, 91054, Erlangen, Germany aut Twardella D. Bavarian Health and Food Safety Authority, Department of Environmental Health, Veterinaerstrasse 2, 85764, Oberschleissheim, Germany aut Angerer J. Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen-Nuremberg, Schillerstrasse 25/29, 91054, Erlangen, Germany aut Boehmer S. Bavarian Health and Food Safety Authority, Department of Environmental Health, Veterinaerstrasse 2, 85764, Oberschleissheim, Germany aut Liebl B. Bavarian State Ministry of Environment, Health and Consumer Protection, Rosenkavalierplatz 2, 81925, Munich, Germany aut International Archives of Occupational and Environmental Health Springer-Verlag 80/4(2007-02-01), 313-319 0340-0131 80:4<313 2007 80 420 https://doi.org/10.1007/s00420-006-0136-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00420-006-0136-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fromme H. Bavarian Health and Food Safety Authority, Department of Environmental Health, Veterinaerstrasse 2, 85764, Oberschleissheim, Germany aut NATIONALLICENCE 700 1- Midasch O. Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen-Nuremberg, Schillerstrasse 25/29, 91054, Erlangen, Germany aut NATIONALLICENCE 700 1- Twardella D. Bavarian Health and Food Safety Authority, Department of Environmental Health, Veterinaerstrasse 2, 85764, Oberschleissheim, Germany aut NATIONALLICENCE 700 1- Angerer J. Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen-Nuremberg, Schillerstrasse 25/29, 91054, Erlangen, Germany aut NATIONALLICENCE 700 1- Boehmer S. Bavarian Health and Food Safety Authority, Department of Environmental Health, Veterinaerstrasse 2, 85764, Oberschleissheim, Germany aut NATIONALLICENCE 700 1- Liebl B. Bavarian State Ministry of Environment, Health and Consumer Protection, Rosenkavalierplatz 2, 81925, Munich, Germany aut NATIONALLICENCE 773 0- International Archives of Occupational and Environmental Health Springer-Verlag 80/4(2007-02-01), 313-319 0340-0131 80:4<313 2007 80 420 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer