caa a22 4500 463194349 CHVBK 20180406164918.0 cr unu---uuuuu 170326e20070201xx s 000 0 eng 10.1007/s00420-006-0125-4 doi (NATIONALLICENCE)springer-10.1007/s00420-006-0125-4 Inverse relationship between serum erythropoietin and blood lead concentrations in Kathmandu tricycle taxi drivers [Elektronische Daten] [Susumu Sakata, Satoshi Shimizu, Kumiko Ogoshi, Kazuko Hirai, Yoshimi Ohno, Takashi Kishi, Jeevan B. Sherchand, Masako Utsumi, Munetaka Shibata, Miyako Takaki, Masatsugu Ueda, Ippei Mori] Objective: Kathmandu tricycle taxi drivers, whose environmental lead (Pb) exposure is ascribable mainly to vehicular exhaust, were studied to examine a dose-response relationship between blood Pb (Pb-B) and serum erythropoietin (sEPO) concentrations. Methods: Subjects were 27 drivers and 9 non-drivers. They were non-anemic healthy men with normal renal function. Pb-B was measured by an atomic absorption spectrometer with a graphite furnace, and sEPO was determined with a sandwich-type enzyme-linked immunosorbent assay. Results: sEPO levels in drivers were lower than those of non-drivers, while Pb-B levels in drivers were higher than those of non-drivers. There was an inverse relationship between Pb-B and sEPO. Conclusions: The data suggest that Pb inhibits renal EPO production in a dose-dependent manner in persons with subclinical Pb toxicity. sEPO may serve as an early biochemical marker of subclinical Pb toxicity. Springer-Verlag, 2006 Erythropoietin nationallicence Lead nationallicence Occupational exposure nationallicence Taxi driver nationallicence Sakata Susumu Department of Physiology II, Nara Medical University, 840 Shijo-cho, 634-8521, Kashihara, Nara, Japan aut Shimizu Satoshi Department of Exercise Physiology, Faculty of Health, Budo & Sports Studies, Tenri University, Tenri, Nara, Japan aut Ogoshi Kumiko Department of Public Health, Nara Medical University, 634-8521, Kashihara, Nara, Japan aut Hirai Kazuko Department of Food and Nutrition, Faculty of Human Life Sciences, Senri Kinran University, Suita, Osaka, Japan aut Ohno Yoshimi Department of Food and Nutrition, School of Human Environmental Sciences, Mukogawa Women's University, Nishinomiya, Hyogo, Japan aut Kishi Takashi Department of Physiology II, Nara Medical University, 840 Shijo-cho, 634-8521, Kashihara, Nara, Japan aut Sherchand Jeevan B. Department of Community Medicine and Family Health, Institute of Medicine, Tribhuvan University, Kathmandu, Nepal aut Utsumi Masako Department of Anatomy I, Nara Medical University, 634-8521, Kashihara, Nara, Japan aut Shibata Munetaka Department of Physiology II, Nara Medical University, 840 Shijo-cho, 634-8521, Kashihara, Nara, Japan aut Takaki Miyako Department of Physiology II, Nara Medical University, 840 Shijo-cho, 634-8521, Kashihara, Nara, Japan aut Ueda Masatsugu YS New Technology Institute, Shimotsuga-gun, Tochigi, Japan aut Mori Ippei Division of Hazard Assessment, National Institute of Industrial Health, Ministry of Labor, Kawasaki, Kanagawa, Japan aut International Archives of Occupational and Environmental Health Springer-Verlag 80/4(2007-02-01), 342-345 0340-0131 80:4<342 2007 80 420 https://doi.org/10.1007/s00420-006-0125-4 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00420-006-0125-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sakata Susumu Department of Physiology II, Nara Medical University, 840 Shijo-cho, 634-8521, Kashihara, Nara, Japan aut NATIONALLICENCE 700 1- Shimizu Satoshi Department of Exercise Physiology, Faculty of Health, Budo & Sports Studies, Tenri University, Tenri, Nara, Japan aut NATIONALLICENCE 700 1- Ogoshi Kumiko Department of Public Health, Nara Medical University, 634-8521, Kashihara, Nara, Japan aut NATIONALLICENCE 700 1- Hirai Kazuko Department of Food and Nutrition, Faculty of Human Life Sciences, Senri Kinran University, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Ohno Yoshimi Department of Food and Nutrition, School of Human Environmental Sciences, Mukogawa Women's University, Nishinomiya, Hyogo, Japan aut NATIONALLICENCE 700 1- Kishi Takashi Department of Physiology II, Nara Medical University, 840 Shijo-cho, 634-8521, Kashihara, Nara, Japan aut NATIONALLICENCE 700 1- Sherchand Jeevan B. Department of Community Medicine and Family Health, Institute of Medicine, Tribhuvan University, Kathmandu, Nepal aut NATIONALLICENCE 700 1- Utsumi Masako Department of Anatomy I, Nara Medical University, 634-8521, Kashihara, Nara, Japan aut NATIONALLICENCE 700 1- Shibata Munetaka Department of Physiology II, Nara Medical University, 840 Shijo-cho, 634-8521, Kashihara, Nara, Japan aut NATIONALLICENCE 700 1- Takaki Miyako Department of Physiology II, Nara Medical University, 840 Shijo-cho, 634-8521, Kashihara, Nara, Japan aut NATIONALLICENCE 700 1- Ueda Masatsugu YS New Technology Institute, Shimotsuga-gun, Tochigi, Japan aut NATIONALLICENCE 700 1- Mori Ippei Division of Hazard Assessment, National Institute of Industrial Health, Ministry of Labor, Kawasaki, Kanagawa, Japan aut NATIONALLICENCE 773 0- International Archives of Occupational and Environmental Health Springer-Verlag 80/4(2007-02-01), 342-345 0340-0131 80:4<342 2007 80 420 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer