caa a22 4500 463194373 CHVBK 20180406164918.0 cr unu---uuuuu 170326e20070201xx s 000 0 eng 10.1007/s00420-006-0137-0 doi (NATIONALLICENCE)springer-10.1007/s00420-006-0137-0 Effects of work related confounders on the association between silica exposure and lung cancer: a nested case-control study among Chinese miners and pottery workers [Elektronische Daten] [Weihong Chen, Frank Bochmann, Yi Sun] Objective: The role of silica in the causation of lung cancer is an ongoing debate. In order to explore whether observed association between silica exposure and lung cancer is confounded by exposure to other occupational carcinogens, we updated a previously nested case-control study among a cohort of male workers in 29 Chinese mines and factories on the basis of an extended follow-up. Methods: Five hundred and eleven lung cancer cases and 1,879 matched controls were selected. Exposure to respirable silica as well as relevant occupational confounders were quantitatively assessed based on historical industrial hygiene data. The relationship between exposure to silica and lung cancer was analyzed by conditional logistic regression analysis adjusted for exposure to arsenic, polycyclic aromatic hydrocarbons (PAHs), radon, and smoking. Results: In a crude analysis adjusted for smoking only, a significant trend of increasing risk of lung cancer with exposure to silica was found for tin, iron/copper miners, and pottery workers. But after adjustment for relevant occupational confounders, no relationship between silica and lung cancer can be observed. Instead, there is a significant association between lung cancer mortality and cumulative exposure to inorganic arsenic (OR=1.86, 95% CI: 1.14, 3.04 for each mg/m3-year increase) and carcinogenic PAHs (OR=1.35, 95% CI: 1.08, 1.69 for each 100μg/m3-year increase). Conclusion: This analysis does not provide any evidence to show that exposure to silica causes lung cancer in the absence of confounding factors. Springer-Verlag, 2006 Crystalline silica nationallicence Lung cancer nationallicence Nested case-control study nationallicence Occupational confounder nationallicence Chen Weihong Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China aut Bochmann Frank Department of Applied Epidemiology, BG-Institute for Occupational Safety and Health (of HVBG), Alte Heerstraße 111, 53797, Sankt Augustin, Germany aut Sun Yi Department of Applied Epidemiology, BG-Institute for Occupational Safety and Health (of HVBG), Alte Heerstraße 111, 53797, Sankt Augustin, Germany aut International Archives of Occupational and Environmental Health Springer-Verlag 80/4(2007-02-01), 320-326 0340-0131 80:4<320 2007 80 420 https://doi.org/10.1007/s00420-006-0137-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00420-006-0137-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chen Weihong Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China aut NATIONALLICENCE 700 1- Bochmann Frank Department of Applied Epidemiology, BG-Institute for Occupational Safety and Health (of HVBG), Alte Heerstraße 111, 53797, Sankt Augustin, Germany aut NATIONALLICENCE 700 1- Sun Yi Department of Applied Epidemiology, BG-Institute for Occupational Safety and Health (of HVBG), Alte Heerstraße 111, 53797, Sankt Augustin, Germany aut NATIONALLICENCE 773 0- International Archives of Occupational and Environmental Health Springer-Verlag 80/4(2007-02-01), 320-326 0340-0131 80:4<320 2007 80 420 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer