caa a22 4500 46319442X CHVBK 20180406164918.0 cr unu---uuuuu 170326e20070801xx s 000 0 eng 10.1007/s00420-007-0181-4 doi (NATIONALLICENCE)springer-10.1007/s00420-007-0181-4 Monitoring of platinum surface contamination in seven Dutch hospital pharmacies using inductively coupled plasma mass spectrometry [Elektronische Daten] [E. Brouwers, A. Huitema, E. Bakker, J. Douma, K. Schimmel, G. van Weringh, P. de Wolf, J. Schellens, J. Beijnen] Objective:: To develop, validate, and apply a method for the determination of platinum contamination, originating from cisplatinum, oxaliplatinum, and carboplatinum. Methods:: Inductively coupled plasma mass spectrometry (ICP-MS) was used to determine platinum in wipe samples. The sampling procedure and the analytical conditions were optimised and the assay was validated. The method was applied to measure surface contamination in seven Dutch hospital pharmacies. Results:: The developed method allowed reproducible quantification of 0.50ngl−1 platinum (5pg/wipe sample). Recoveries for stainless steel and linoleum surfaces ranged between 50.4 and 81.4% for the different platinum compounds tested. Platinum contamination was reported in 88% of the wipe samples. Although a substantial variation in surface contamination of the pharmacies was noticed, in most pharmacies, the laminar-airflow (LAF) hoods, the floor in front of the LAF hoods, door handles, and handles of service hatches showed positive results. This demonstrates that contamination is spread throughout the preparation rooms. Conclusion:: We developed and validated an ultra sensitive and reliable ICP-MS method for the determination of platinum in surface samples. Surface contamination with platinum was observed in all hospital pharmacies sampled. The interpretation of these results is, however, complicated. Springer-Verlag, 2007 ICP-MS nationallicence Platinum nationallicence Validation nationallicence Hospital pharmacies nationallicence Surface contamination nationallicence Brouwers E. Department of Pharmacy and Pharmacology, Slotervaart Hospital/The Netherlands Cancer Institute, Louwesweg 6, 1066 EC, Amsterdam, The Netherlands aut Huitema A. Department of Pharmacy and Pharmacology, Slotervaart Hospital/The Netherlands Cancer Institute, Louwesweg 6, 1066 EC, Amsterdam, The Netherlands aut Bakker E. Department of Clinical Pharmacology and Pharmacy, Free University Medical Centre, de Boelelaan 1117, 1007 MB, Amsterdam, The Netherlands aut Douma J. Department of Pharmacy, University Medical Centre, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands aut Schimmel K. Department of Clinical Pharmacy and Toxicology, Leiden University Medical Centre, Albinusdreef 2, 2300 RC, Leiden, The Netherlands aut van Weringh G. Department of Pharmacy, Sint Lucas Andreas Hospital, Jan Tooropstraat 164, 1061 AE, Amsterdam, The Netherlands aut de Wolf P. Hospital Pharmacy of Haarlem, Boerhaavelaan 24, 2035 RC, Haarlem, The Netherlands aut Schellens J. Department of Biomedical Analysis, Faculty of Pharmaceutical Sciences, Utrecht University, P.O. Box 80082, 3508 TB, Utrecht, The Netherlands aut Beijnen J. Department of Pharmacy and Pharmacology, Slotervaart Hospital/The Netherlands Cancer Institute, Louwesweg 6, 1066 EC, Amsterdam, The Netherlands aut International Archives of Occupational and Environmental Health Springer-Verlag 80/8(2007-08-01), 689-699 0340-0131 80:8<689 2007 80 420 https://doi.org/10.1007/s00420-007-0181-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00420-007-0181-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Brouwers E. Department of Pharmacy and Pharmacology, Slotervaart Hospital/The Netherlands Cancer Institute, Louwesweg 6, 1066 EC, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Huitema A. Department of Pharmacy and Pharmacology, Slotervaart Hospital/The Netherlands Cancer Institute, Louwesweg 6, 1066 EC, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Bakker E. Department of Clinical Pharmacology and Pharmacy, Free University Medical Centre, de Boelelaan 1117, 1007 MB, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Douma J. Department of Pharmacy, University Medical Centre, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands aut NATIONALLICENCE 700 1- Schimmel K. Department of Clinical Pharmacy and Toxicology, Leiden University Medical Centre, Albinusdreef 2, 2300 RC, Leiden, The Netherlands aut NATIONALLICENCE 700 1- van Weringh G. Department of Pharmacy, Sint Lucas Andreas Hospital, Jan Tooropstraat 164, 1061 AE, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- de Wolf P. Hospital Pharmacy of Haarlem, Boerhaavelaan 24, 2035 RC, Haarlem, The Netherlands aut NATIONALLICENCE 700 1- Schellens J. Department of Biomedical Analysis, Faculty of Pharmaceutical Sciences, Utrecht University, P.O. Box 80082, 3508 TB, Utrecht, The Netherlands aut NATIONALLICENCE 700 1- Beijnen J. Department of Pharmacy and Pharmacology, Slotervaart Hospital/The Netherlands Cancer Institute, Louwesweg 6, 1066 EC, Amsterdam, The Netherlands aut NATIONALLICENCE 773 0- International Archives of Occupational and Environmental Health Springer-Verlag 80/8(2007-08-01), 689-699 0340-0131 80:8<689 2007 80 420 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer