caa a22 4500 463194438 CHVBK 20180406164918.0 cr unu---uuuuu 170326e20070801xx s 000 0 eng 10.1007/s00420-007-0178-z doi (NATIONALLICENCE)springer-10.1007/s00420-007-0178-z 1-Hydroxypyrene as a biomarker of PAH exposure among subjects living in two separate regions from a steel mill [Elektronische Daten] [Mi-Sun Lee, Ki-Do Eum, Kyung-Duk Zoh, Tak-Soo Kim, Yun-Suk Pak, Domyung Paek] Objective: Steel mills are known to be a source of ambient polycyclic aromatic hydrocarbons (PAHs), and increased cancer risk has been reported among neighborhoods previously. In this study, we tried to assess the exposure to PAHs among residents nearby to a large steel mill in Korea by measuring urinary 1-hydroxypyrene (1-OHP). Methods: Two separate areas at different distances from a steel mill but on the same wind direction were chosen to evaluate the environmental exposures to polycyclic aromatic hydrocarbons. Three-hundred and fifty children living in the vicinity of steel plant ("nearby” group) and 606 children residing much farther from the factory ("remote” group) participated. Urine was collected on three consecutive days, and questionnaires about exposure to passive smoking and food consumption as well as demographics were obtained. Routine monitoring data of ambient pollutants were obtained and particulate matter less than 10μm (PM10) was analyzed with multiple regressions to assess the associations with urinary 1-OHP. Results: The geometric mean concentration of urinary 1-OHP among nearby group (0.048±1.878 μmol/mol creatinine, GM±GSD) was approximately 1.3 times higher than that among remote group (0.036±2.425 μmol/mol creatinine, GM±GSD), and using multiple regression techniques, the difference was significant (P<0.0001) after adjusting for confounding variables. When different periods before the sampling of urine were examined, PM10 averages over 2days, 3days, and 1week prior to urine sampling showed significant associations with urinary 1-OHP levels. Conclusion: Our findings are consistent with the interpretation that residents nearby to a steel mill are exposed to PAHs through ambient exposures. Springer-Verlag, 2007 1-hydroxypyrene nationallicence Polycyclic aromatic hydrocarbons nationallicence Particulate matter nationallicence Steel plant nationallicence Children nationallicence Lee Mi-Sun Department of Occupational and Environmental Medicine, School of Public Health, Seoul National University, 28 Yeunkun-Dong, Jongno-Gu, 110-460, Seoul, Republic of Korea aut Eum Ki-Do Department of Occupational and Environmental Medicine, School of Public Health, Seoul National University, 28 Yeunkun-Dong, Jongno-Gu, 110-460, Seoul, Republic of Korea aut Zoh Kyung-Duk Department of Environmental Health, School of Public Health and Institute of Health and Environment, Seoul National University, Seoul, Republic of Korea aut Kim Tak-Soo Yeongsan River Basin Environmental Office, Ministry of Environment, 760-2 Ilgok-dong, Buk-gu, 500-727, Gwangju, Republic of Korea aut Pak Yun-Suk Department of Occupational and Environmental Medicine, School of Public Health, Seoul National University, 28 Yeunkun-Dong, Jongno-Gu, 110-460, Seoul, Republic of Korea aut Paek Domyung Department of Occupational and Environmental Medicine, School of Public Health, Seoul National University, 28 Yeunkun-Dong, Jongno-Gu, 110-460, Seoul, Republic of Korea aut International Archives of Occupational and Environmental Health Springer-Verlag 80/8(2007-08-01), 671-678 0340-0131 80:8<671 2007 80 420 https://doi.org/10.1007/s00420-007-0178-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00420-007-0178-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lee Mi-Sun Department of Occupational and Environmental Medicine, School of Public Health, Seoul National University, 28 Yeunkun-Dong, Jongno-Gu, 110-460, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- Eum Ki-Do Department of Occupational and Environmental Medicine, School of Public Health, Seoul National University, 28 Yeunkun-Dong, Jongno-Gu, 110-460, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- Zoh Kyung-Duk Department of Environmental Health, School of Public Health and Institute of Health and Environment, Seoul National University, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- Kim Tak-Soo Yeongsan River Basin Environmental Office, Ministry of Environment, 760-2 Ilgok-dong, Buk-gu, 500-727, Gwangju, Republic of Korea aut NATIONALLICENCE 700 1- Pak Yun-Suk Department of Occupational and Environmental Medicine, School of Public Health, Seoul National University, 28 Yeunkun-Dong, Jongno-Gu, 110-460, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- Paek Domyung Department of Occupational and Environmental Medicine, School of Public Health, Seoul National University, 28 Yeunkun-Dong, Jongno-Gu, 110-460, Seoul, Republic of Korea aut NATIONALLICENCE 773 0- International Archives of Occupational and Environmental Health Springer-Verlag 80/8(2007-08-01), 671-678 0340-0131 80:8<671 2007 80 420 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer