caa a22 4500 463194551 CHVBK 20180406164919.0 cr unu---uuuuu 170326e20070401xx s 000 0 eng 10.1007/s00420-006-0145-0 doi (NATIONALLICENCE)springer-10.1007/s00420-006-0145-0 Exposure-response relationship between endotoxin exposure and lung function impairment in cotton textile workers [Elektronische Daten] [Marcus Oldenburg, Ute Latza, Xaver Baur] Objectives: Preventive workplace regulations are so far not based on an ubiquitously accepted threshold for airborne endotoxin in the bioaerosol. Methods: In a cross-sectional study, 150 employees of a cotton spinning mill underwent lung function testing. Furthermore, in a random subset of 75 textile workers cross-shift lung function test and methacholine challenges were performed. Airborne current endotoxin exposure was classified as "low”, "medium”, and "high” (≤100,>100-≤450, and>450 Endotoxin Units (EU)/m3, respectively) based on endotoxin activity. Results: The exposure-response relationship between current endotoxin exposure and prevalence of an obstructive ventilation pattern was significant (test for linear trend: P=0.019); the adjusted odds ratio for high endotoxin exposure was 11.22 (95% confidence interval 1.03-121.17). Within individuals, FEV1/FVC% was significantly reduced after the shift (paired t test: P=0.009) but not related to current endotoxin exposure. Twelve workers showed bronchial hyperresponsiveness (8.1% before and 12.2% after the work shift; Fisher's exact test: P=0.021). Conclusion: The study among German cotton textile workers suggests an exposure-dependent effect of current endotoxin exposure on lung function impairment with significant effects above 450EU/m3. Springer-Verlag, 2006 Endotoxin nationallicence Lung function nationallicence Exposure-response relationship nationallicence Textile workers nationallicence Cross-shift nationallicence Oldenburg Marcus Clinical Occupational Medicine, Institute of Occupational Medicine (ZfA), University of Hamburg, Hamburg, Germany aut Latza Ute Clinical Occupational Medicine, Institute of Occupational Medicine (ZfA), University of Hamburg, Hamburg, Germany aut Baur Xaver Clinical Occupational Medicine, Institute of Occupational Medicine (ZfA), University of Hamburg, Hamburg, Germany aut International Archives of Occupational and Environmental Health Springer-Verlag 80/5(2007-04-01), 388-395 0340-0131 80:5<388 2007 80 420 https://doi.org/10.1007/s00420-006-0145-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00420-006-0145-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Oldenburg Marcus Clinical Occupational Medicine, Institute of Occupational Medicine (ZfA), University of Hamburg, Hamburg, Germany aut NATIONALLICENCE 700 1- Latza Ute Clinical Occupational Medicine, Institute of Occupational Medicine (ZfA), University of Hamburg, Hamburg, Germany aut NATIONALLICENCE 700 1- Baur Xaver Clinical Occupational Medicine, Institute of Occupational Medicine (ZfA), University of Hamburg, Hamburg, Germany aut NATIONALLICENCE 773 0- International Archives of Occupational and Environmental Health Springer-Verlag 80/5(2007-04-01), 388-395 0340-0131 80:5<388 2007 80 420 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer