caa a22 4500 463194721 CHVBK 20180406164919.0 cr unu---uuuuu 170326e20070301xx s 000 0 eng 10.1007/s10669-007-9024-9 doi (NATIONALLICENCE)springer-10.1007/s10669-007-9024-9 Review of the methods used for isolating pharmaceutical lead compounds from traditional medicinal plants [Elektronische Daten] [J. McRae, Q. Yang, R. Crawford, E. Palombo] The possibility of finding new medicines from natural sources is one of the more commonly cited reasons for preserving biodiversity, and employing indigenous knowledge of traditional healing remedies greatly increases the likelihood of discovering these hidden medicinal compounds. The main difficulties in using natural products as a source for pharmaceutical lead compounds involve separating the plethora of compounds from the original extract, as well as the gamble of time and money invested in an activity that may not yield a novel compound. However, while these difficulties exist, the potential of natural products still far outweighs the limitations of the simple structures and known modes of action of synthetic lead compounds. As such, the production of novel medicines, particularly for cancer and human immunodeficiency virus (HIV) treatments as well as the inhibition of antibiotic-resistant bacteria, now requires the utilization of natural products. This paper provides a review of the current methods used in elucidating pharmaceutical lead compounds from natural sources, focusing on plant samples in particular. Springer Science+Business Media, LLC, 2007 Bioactivity nationallicence Lead compounds nationallicence Medicinal plants nationallicence Natural products chemistry nationallicence Phytochemistry nationallicence McRae J. Environment and Biotechnology Centre, Faculty of Life and Social Sciences, Swinburne University of Technology, VIC, 3122, Hawthorn, Australia aut Yang Q. CSIRO Molecular and Health Technologies, VIC, 3169, Clayton, Australia aut Crawford R. Environment and Biotechnology Centre, Faculty of Life and Social Sciences, Swinburne University of Technology, VIC, 3122, Hawthorn, Australia aut Palombo E. Environment and Biotechnology Centre, Faculty of Life and Social Sciences, Swinburne University of Technology, VIC, 3122, Hawthorn, Australia aut The Environmentalist Kluwer Academic Publishers-Plenum Publishers; http://www.springer-ny.com 27/1(2007-03-01), 165-174 0251-1088 27:1<165 2007 27 10669 https://doi.org/10.1007/s10669-007-9024-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10669-007-9024-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- McRae J. Environment and Biotechnology Centre, Faculty of Life and Social Sciences, Swinburne University of Technology, VIC, 3122, Hawthorn, Australia aut NATIONALLICENCE 700 1- Yang Q. CSIRO Molecular and Health Technologies, VIC, 3169, Clayton, Australia aut NATIONALLICENCE 700 1- Crawford R. Environment and Biotechnology Centre, Faculty of Life and Social Sciences, Swinburne University of Technology, VIC, 3122, Hawthorn, Australia aut NATIONALLICENCE 700 1- Palombo E. Environment and Biotechnology Centre, Faculty of Life and Social Sciences, Swinburne University of Technology, VIC, 3122, Hawthorn, Australia aut NATIONALLICENCE 773 0- The Environmentalist Kluwer Academic Publishers-Plenum Publishers; http://www.springer-ny.com 27/1(2007-03-01), 165-174 0251-1088 27:1<165 2007 27 10669 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer