caa a22 4500 463198956 CHVBK 20180406164930.0 cr unu---uuuuu 170326e20070201xx s 000 0 eng 10.1007/s00276-006-0163-3 doi (NATIONALLICENCE)springer-10.1007/s00276-006-0163-3 Could linear MRI measurements of hippocampus differentiate normal brain aging in elderly persons from Alzheimer disease? [Elektronische Daten] [Abdullah Tarroun, Marc Bonnefoy, Juliette Bouffard-Vercelli, Claire Gedeon, Bernard Vallee, François Cotton] Although mild progressive specific structural brain changes are commonly associated with normal human aging, it is unclear whether automatic or manual measurements of these structures can differentiate normal brain aging in elderly persons from patients suffering from cognitive impairment. The objective of this study was primarily to define, with a standard high resolution MRI, the range of normal linear age-specific values for the hippocampal formation (HF), and secondarily to differentiate hippocampal atrophy in normal aging from that occurring in Alzheimer disease (AD). Two MRI-based linear measurements of the hippocampal formation at the level of the head and of the tail, standardized by the cranial dimensions, were obtained from coronal and sagittal T1-weighted MR images in 25 normal elderly subjects, and 26 patients with AD. In this study, dimensions of the HF have been standardized and they revealed normal distributions for each side and each sex: the width of the hippocampal head at the level of the amygdala was 16.42±1.9mm, and its height 7.93±1.4mm; the width of the tail at the level of the cerebral aqueduct was 8.54±1.2mm, and the height 5.74±0.4mm. There were no significant differences in standardized dimensions of the HF between sides, sexes, or in comparison to head dimensions in the two groups. In addition, the median inter-observer agreement index was 93%. In contrast, the dimensions of the hippocampal formation decreased gradually with increasing age, owing to physiological atrophy, but this atrophy is more significant in the group of AD. Springer-Verlag, 2006 Alzheimer disease nationallicence Aging nationallicence Hippocampus nationallicence MRI nationallicence Temporal lobe nationallicence Anatomy nationallicence Brain nationallicence Tarroun Abdullah MRI Center, Lyon Sud Hospital, 69495, Pierre Benite, France aut Bonnefoy Marc Geriatric Department, Lyon Sud Hospital, 69495, Pierre Benite, France aut Bouffard-Vercelli Juliette MRI Center, Lyon Sud Hospital, 69495, Pierre Benite, France aut Gedeon Claire Geriatric Department, Lyon Sud Hospital, 69495, Pierre Benite, France aut Vallee Bernard Anatomy Department, Laennec Rockefeller University, Avenue Rockefeller, 69373, Lyon Cedex 08, France aut Cotton François MRI Center, Lyon Sud Hospital, 69495, Pierre Benite, France aut Surgical and Radiologic Anatomy Springer-Verlag 29/1(2007-02-01), 77-81 0930-1038 29:1<77 2007 29 276 https://doi.org/10.1007/s00276-006-0163-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00276-006-0163-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tarroun Abdullah MRI Center, Lyon Sud Hospital, 69495, Pierre Benite, France aut NATIONALLICENCE 700 1- Bonnefoy Marc Geriatric Department, Lyon Sud Hospital, 69495, Pierre Benite, France aut NATIONALLICENCE 700 1- Bouffard-Vercelli Juliette MRI Center, Lyon Sud Hospital, 69495, Pierre Benite, France aut NATIONALLICENCE 700 1- Gedeon Claire Geriatric Department, Lyon Sud Hospital, 69495, Pierre Benite, France aut NATIONALLICENCE 700 1- Vallee Bernard Anatomy Department, Laennec Rockefeller University, Avenue Rockefeller, 69373, Lyon Cedex 08, France aut NATIONALLICENCE 700 1- Cotton François MRI Center, Lyon Sud Hospital, 69495, Pierre Benite, France aut NATIONALLICENCE 773 0- Surgical and Radiologic Anatomy Springer-Verlag 29/1(2007-02-01), 77-81 0930-1038 29:1<77 2007 29 276 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer