caa a22 4500 463200578 CHVBK 20180405153111.0 cr unu---uuuuu 170326e20070501xx s 000 0 eng 10.1007/s10014-007-0214-4 doi (NATIONALLICENCE)springer-10.1007/s10014-007-0214-4 Early effects of boron neutron capture therapy on rat glioma models [Elektronische Daten] [Nobuhiro Nakagawa, Fumiharu Akai, Norihito Fukawa, Yoshihiko Fujita, Minoru Suzuki, Koji Ono, Mamoru Taneda] Early effects of boron neutron capture therapy (BNCT) on malignant glioma are characterized by reduction of the enhancement area and regression of the peritumoral edema radiologically. The aim of this study was to investigate the early histological changes of tumors and inflammatory cells after BNCT in the rat brain. Rats were treated with BNCT using boronophenylalanine (BPA) 7 days after implantation of C6 glioma cells. The tumors were assessed with magnetic resonance imaging and histopathological examination at 4 days after BNCT. The mean tumor volumes were 39 ± 2 mm3 in the BNCT group and 134 ± 18 mm3 in the control group. In the BNCT group, tumor cells showed a less pleomorphic appearance with atypical nuclei and mitotic figures. The Ki-67 labeling index was 6.5% ± 4.7% in the BNCT and 35% ± 3.8% in the control group. The reactions of the inflammatory cells were examined with ED-1 as macrophage marker and OX42 as microglia marker. ED-1- and OX-42-positive cells were reduced both in the core and the marginal area of the tumor in the BNCT group. It is suggested that BNCT reduced tumor progression by suppression of proliferation. Inhibition of the activated macrophages may relate to reduced peritumoral edema in the early phase. The Japan Society of Brain Tumor Pathology, 2007 Boron neutron capture therapy nationallicence Boronophenylalanine nationallicence Glioma nationallicence Microglia nationallicence Macrophage nationallicence Nakagawa Nobuhiro Department of Neurosurgery, Kinki University School of Medicine, 377-2 Ohnohigashi, Osakasayama, 589-8511, Osaka, Japan aut Akai Fumiharu Department of Neurosurgery, Kinki University School of Medicine, 377-2 Ohnohigashi, Osakasayama, 589-8511, Osaka, Japan aut Fukawa Norihito Department of Neurosurgery, Kinki University School of Medicine, 377-2 Ohnohigashi, Osakasayama, 589-8511, Osaka, Japan aut Fujita Yoshihiko Genome Biology, Kinki University School of Medicine, Osaka, Japan aut Suzuki Minoru Research Reactor Institute, Kyoto University, Osaka, Japan aut Ono Koji Research Reactor Institute, Kyoto University, Osaka, Japan aut Taneda Mamoru Department of Neurosurgery, Kinki University School of Medicine, 377-2 Ohnohigashi, Osakasayama, 589-8511, Osaka, Japan aut Brain Tumor Pathology Springer-Verlag 24/1(2007-05-01), 7-13 1433-7398 24:1<7 2007 24 10014 https://doi.org/10.1007/s10014-007-0214-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10014-007-0214-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nakagawa Nobuhiro Department of Neurosurgery, Kinki University School of Medicine, 377-2 Ohnohigashi, Osakasayama, 589-8511, Osaka, Japan aut NATIONALLICENCE 700 1- Akai Fumiharu Department of Neurosurgery, Kinki University School of Medicine, 377-2 Ohnohigashi, Osakasayama, 589-8511, Osaka, Japan aut NATIONALLICENCE 700 1- Fukawa Norihito Department of Neurosurgery, Kinki University School of Medicine, 377-2 Ohnohigashi, Osakasayama, 589-8511, Osaka, Japan aut NATIONALLICENCE 700 1- Fujita Yoshihiko Genome Biology, Kinki University School of Medicine, Osaka, Japan aut NATIONALLICENCE 700 1- Suzuki Minoru Research Reactor Institute, Kyoto University, Osaka, Japan aut NATIONALLICENCE 700 1- Ono Koji Research Reactor Institute, Kyoto University, Osaka, Japan aut NATIONALLICENCE 700 1- Taneda Mamoru Department of Neurosurgery, Kinki University School of Medicine, 377-2 Ohnohigashi, Osakasayama, 589-8511, Osaka, Japan aut NATIONALLICENCE 773 0- Brain Tumor Pathology Springer-Verlag 24/1(2007-05-01), 7-13 1433-7398 24:1<7 2007 24 10014 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer