caa a22 4500 463200632 CHVBK 20180405153111.0 cr unu---uuuuu 170326e20071101xx s 000 0 eng 10.1007/s10014-007-0223-3 doi (NATIONALLICENCE)springer-10.1007/s10014-007-0223-3 Fluorescence-guided resection of metastatic brain tumors using a 5-aminolevulinic acid-induced protoporphyrin IX: pathological study [Elektronische Daten] [Satoshi Utsuki, Norio Miyoshi, Hidehiro Oka, Yoshiteru Miyajima, Satoru Shimizu, Sachio Suzuki, Kiyotaka Fujii] We performed a pathological study to identify the locus of production of protoporphyrin IX (PPIX) in human metastatic brain tumors. Patients with metastatic brain tumors (n = 11) received 1 g of 5-aminolevulinic acid (5-ALA) perorally 2 h before undergoing surgery. The target region was exposed to laser light with a peak wavelength of 405 ± 1 nm and an output of 40 mW. Tissue samples from the tumor bulk and surrounding areas were examined by histological and fluorescence methods. Of the 11 tumors, 9 manifested PPIX fluorescence in the tumor bulk and peritumoral brain tissue. Our findings indicate that PPIX fluorescence can be observed in peritumoral edematous areas that are free of neoplastic cells, because PPIX produced by neoplastic cells leaks into the surrounding edematous area. The Japan Society of Brain Tumor Pathology, 2007 5-Aminolevulinic acid nationallicence Fluorescence diagnosis nationallicence Metastatic brain tumor nationallicence Protoporphyrin IX nationallicence Utsuki Satoshi Department of Neurosurgery, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara, 228-8555, Kanagawa, Japan aut Miyoshi Norio Department of Pathology, Faculty of Medicine, University of Fukui, Fukui, Japan aut Oka Hidehiro Department of Neurosurgery, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara, 228-8555, Kanagawa, Japan aut Miyajima Yoshiteru Department of Neurosurgery, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara, 228-8555, Kanagawa, Japan aut Shimizu Satoru Department of Neurosurgery, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara, 228-8555, Kanagawa, Japan aut Suzuki Sachio Department of Neurosurgery, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara, 228-8555, Kanagawa, Japan aut Fujii Kiyotaka Department of Neurosurgery, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara, 228-8555, Kanagawa, Japan aut Brain Tumor Pathology Springer-Verlag 24/2(2007-11-01), 53-55 1433-7398 24:2<53 2007 24 10014 https://doi.org/10.1007/s10014-007-0223-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10014-007-0223-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Utsuki Satoshi Department of Neurosurgery, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara, 228-8555, Kanagawa, Japan aut NATIONALLICENCE 700 1- Miyoshi Norio Department of Pathology, Faculty of Medicine, University of Fukui, Fukui, Japan aut NATIONALLICENCE 700 1- Oka Hidehiro Department of Neurosurgery, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara, 228-8555, Kanagawa, Japan aut NATIONALLICENCE 700 1- Miyajima Yoshiteru Department of Neurosurgery, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara, 228-8555, Kanagawa, Japan aut NATIONALLICENCE 700 1- Shimizu Satoru Department of Neurosurgery, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara, 228-8555, Kanagawa, Japan aut NATIONALLICENCE 700 1- Suzuki Sachio Department of Neurosurgery, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara, 228-8555, Kanagawa, Japan aut NATIONALLICENCE 700 1- Fujii Kiyotaka Department of Neurosurgery, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara, 228-8555, Kanagawa, Japan aut NATIONALLICENCE 773 0- Brain Tumor Pathology Springer-Verlag 24/2(2007-11-01), 53-55 1433-7398 24:2<53 2007 24 10014 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer