caa a22 4500 463200659 CHVBK 20180405153111.0 cr unu---uuuuu 170326e20071101xx s 000 0 eng 10.1007/s10014-007-0216-2 doi (NATIONALLICENCE)springer-10.1007/s10014-007-0216-2 Expression of aquaporine-4 in central nervous system tumors [Elektronische Daten] [Tatsuo Sawada, Yoichiro Kato, Makio Kobayashi] Cerebral edema is associated with common brain tumors. Aquaporine-4 (AQP4) is a member of the water channel protein family, which is thought to be a major factor regulating cerebral edema. To elucidate the characterization of the expression of AQP4 and the relationship of the expression of VEGF, we investigated the expression of AQP4 in tumors of the central nervous system immunohistochemically. Brain tumors and nontumorous cerebral tissue for control were evaluated by immunohistochemical staining using anti-AQP4, VEGF, CD34, and MIB-1. In tumor cells, only glial tumor cells showed a positive reaction for AQP4. The reactivities for immunostaining increased according to WHO grades. Reactive glial cells in edematous tissue also showed positive reactions. Although endothelial cells were negative and/or weakly positive for AQP4, the positive relationship suggested the expression of VEGF in endothelial cells in neovasculature and that of AQP 4 in tumor cells. APQ4 expression increased in human astrocytic tumors and edematous cerebral tissue. Upregulation of APQ4 by tumor cells and reactive astroglia were major factors of cerebral edema. The Japan Society of Brain Tumor Pathology, 2007 Aquaporine-4 nationallicence Brain tumor nationallicence Blood-brain barrier nationallicence Cerebral edema nationallicence Immunohistochemstry nationallicence Sawada Tatsuo Department of Pathology, Tokyo Women's Medical University, 8-1 Kawadacho, Shinjuku-ku, 162-8666, Tokyo, Japan aut Kato Yoichiro Department of Pathology, Tokyo Women's Medical University, 8-1 Kawadacho, Shinjuku-ku, 162-8666, Tokyo, Japan aut Kobayashi Makio Department of Pathology, Tokyo Women's Medical University, 8-1 Kawadacho, Shinjuku-ku, 162-8666, Tokyo, Japan aut Brain Tumor Pathology Springer-Verlag 24/2(2007-11-01), 81-84 1433-7398 24:2<81 2007 24 10014 https://doi.org/10.1007/s10014-007-0216-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10014-007-0216-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sawada Tatsuo Department of Pathology, Tokyo Women's Medical University, 8-1 Kawadacho, Shinjuku-ku, 162-8666, Tokyo, Japan aut NATIONALLICENCE 700 1- Kato Yoichiro Department of Pathology, Tokyo Women's Medical University, 8-1 Kawadacho, Shinjuku-ku, 162-8666, Tokyo, Japan aut NATIONALLICENCE 700 1- Kobayashi Makio Department of Pathology, Tokyo Women's Medical University, 8-1 Kawadacho, Shinjuku-ku, 162-8666, Tokyo, Japan aut NATIONALLICENCE 773 0- Brain Tumor Pathology Springer-Verlag 24/2(2007-11-01), 81-84 1433-7398 24:2<81 2007 24 10014 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer