caa a22 4500 463200667 CHVBK 20180405153111.0 cr unu---uuuuu 170326e20071101xx s 000 0 eng 10.1007/s10014-007-0220-6 doi (NATIONALLICENCE)springer-10.1007/s10014-007-0220-6 Hyperprolactinemia and immunohistochemical expression of intracellular prolactin and prolactin receptor in primary central nervous system tumors and their relationship with cellular replication [Elektronische Daten] [Carolina Garcia Soares Leães, Arthur Pereira Filho, Júlia F.S. Pereira Lima, Cristina Micheletto Dallago, Rafael Loch Batista, Lígia M. Barbosa-Coutinho, Nelson Pires Ferreira, Miriam da Costa Oliveira] The role of prolactin (PRL) in the CNS remains uncertain. We evaluated the presence of hyperprolactinemia, intracellular prolactin (ICP), and prolactin receptor (PRL-R) in primary CNS tumors, and their relationship with cellular replication with a prospective cross-sectional study of 82 consecutive patients with primary CNS tumors admitted for neurosurgical resection between October 2003 and September 2005. Patients submitted to a questionnaire, and venous blood samples were obtained for measurement of serum PRL and TSH. Immunohistochemical analyses were performed to evaluate the presence of ICP, PRL-R, and Ki-67. Serum PRL levels ranged from 2 to 70 ng/ml, and hyperprolactinemia was detected in 25 cases (30.5%). ICP was detected in 18 patients (21.9%), in whom PRL ranged from 2 to 32 ng/ml. A positive correlation was found between PRL levels and the presence of ICP (Student's t test, P = 0.022). The PRL-R was observed immunohistochemically in 32 cases (39%). The frequencies of hyperprolactinemia, ICP, and PRL-R were similar across the several histological types of CNS tumors. Ki-67 index was similar in all groups. Hyperprolactinemia and intracellular presence of PRL and PRL-R were common findings in this population, suggesting a role for PRL in CNS tumor genesis. The Japan Society of Brain Tumor Pathology, 2007 Prolactin nationallicence Hyperprolactinemia nationallicence Central nervous system tumor nationallicence Prolactin receptor nationallicence Ki-67 nationallicence Soares Leães Carolina Garcia Department of Pathology of Fundação Faculdade Federal de Ciências Médicas de Porto Alegre, Center of Neuroendocrinology - Complexo Hospitalar Santa Casa of Porto Alegre/RS, Rua Dona Mimi Moro, 40 90480-050, Porto Alegre, RS, Brazil aut Filho Arthur Pereira Department of Pathology of Fundação Faculdade Federal de Ciências Médicas de Porto Alegre, Center of Neuroendocrinology - Complexo Hospitalar Santa Casa of Porto Alegre/RS, Rua Dona Mimi Moro, 40 90480-050, Porto Alegre, RS, Brazil aut Pereira Lima Júlia F.S. Department of Pathology of Fundação Faculdade Federal de Ciências Médicas de Porto Alegre, Center of Neuroendocrinology - Complexo Hospitalar Santa Casa of Porto Alegre/RS, Rua Dona Mimi Moro, 40 90480-050, Porto Alegre, RS, Brazil aut Dallago Cristina Micheletto Department of Pathology of Fundação Faculdade Federal de Ciências Médicas de Porto Alegre, Center of Neuroendocrinology - Complexo Hospitalar Santa Casa of Porto Alegre/RS, Rua Dona Mimi Moro, 40 90480-050, Porto Alegre, RS, Brazil aut Batista Rafael Loch Department of Pathology of Fundação Faculdade Federal de Ciências Médicas de Porto Alegre, Center of Neuroendocrinology - Complexo Hospitalar Santa Casa of Porto Alegre/RS, Rua Dona Mimi Moro, 40 90480-050, Porto Alegre, RS, Brazil aut Barbosa-Coutinho Lígia M. Department of Pathology of Fundação Faculdade Federal de Ciências Médicas de Porto Alegre, Center of Neuroendocrinology - Complexo Hospitalar Santa Casa of Porto Alegre/RS, Rua Dona Mimi Moro, 40 90480-050, Porto Alegre, RS, Brazil aut Ferreira Nelson Pires Department of Pathology of Fundação Faculdade Federal de Ciências Médicas de Porto Alegre, Center of Neuroendocrinology - Complexo Hospitalar Santa Casa of Porto Alegre/RS, Rua Dona Mimi Moro, 40 90480-050, Porto Alegre, RS, Brazil aut da Costa Oliveira Miriam Department of Pathology of Fundação Faculdade Federal de Ciências Médicas de Porto Alegre, Center of Neuroendocrinology - Complexo Hospitalar Santa Casa of Porto Alegre/RS, Rua Dona Mimi Moro, 40 90480-050, Porto Alegre, RS, Brazil aut Brain Tumor Pathology Springer-Verlag 24/2(2007-11-01), 41-46 1433-7398 24:2<41 2007 24 10014 https://doi.org/10.1007/s10014-007-0220-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10014-007-0220-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Soares Leães Carolina Garcia Department of Pathology of Fundação Faculdade Federal de Ciências Médicas de Porto Alegre, Center of Neuroendocrinology - Complexo Hospitalar Santa Casa of Porto Alegre/RS, Rua Dona Mimi Moro, 40 90480-050, Porto Alegre, RS, Brazil aut NATIONALLICENCE 700 1- Filho Arthur Pereira Department of Pathology of Fundação Faculdade Federal de Ciências Médicas de Porto Alegre, Center of Neuroendocrinology - Complexo Hospitalar Santa Casa of Porto Alegre/RS, Rua Dona Mimi Moro, 40 90480-050, Porto Alegre, RS, Brazil aut NATIONALLICENCE 700 1- Pereira Lima Júlia F.S. Department of Pathology of Fundação Faculdade Federal de Ciências Médicas de Porto Alegre, Center of Neuroendocrinology - Complexo Hospitalar Santa Casa of Porto Alegre/RS, Rua Dona Mimi Moro, 40 90480-050, Porto Alegre, RS, Brazil aut NATIONALLICENCE 700 1- Dallago Cristina Micheletto Department of Pathology of Fundação Faculdade Federal de Ciências Médicas de Porto Alegre, Center of Neuroendocrinology - Complexo Hospitalar Santa Casa of Porto Alegre/RS, Rua Dona Mimi Moro, 40 90480-050, Porto Alegre, RS, Brazil aut NATIONALLICENCE 700 1- Batista Rafael Loch Department of Pathology of Fundação Faculdade Federal de Ciências Médicas de Porto Alegre, Center of Neuroendocrinology - Complexo Hospitalar Santa Casa of Porto Alegre/RS, Rua Dona Mimi Moro, 40 90480-050, Porto Alegre, RS, Brazil aut NATIONALLICENCE 700 1- Barbosa-Coutinho Lígia M. Department of Pathology of Fundação Faculdade Federal de Ciências Médicas de Porto Alegre, Center of Neuroendocrinology - Complexo Hospitalar Santa Casa of Porto Alegre/RS, Rua Dona Mimi Moro, 40 90480-050, Porto Alegre, RS, Brazil aut NATIONALLICENCE 700 1- Ferreira Nelson Pires Department of Pathology of Fundação Faculdade Federal de Ciências Médicas de Porto Alegre, Center of Neuroendocrinology - Complexo Hospitalar Santa Casa of Porto Alegre/RS, Rua Dona Mimi Moro, 40 90480-050, Porto Alegre, RS, Brazil aut NATIONALLICENCE 700 1- da Costa Oliveira Miriam Department of Pathology of Fundação Faculdade Federal de Ciências Médicas de Porto Alegre, Center of Neuroendocrinology - Complexo Hospitalar Santa Casa of Porto Alegre/RS, Rua Dona Mimi Moro, 40 90480-050, Porto Alegre, RS, Brazil aut NATIONALLICENCE 773 0- Brain Tumor Pathology Springer-Verlag 24/2(2007-11-01), 41-46 1433-7398 24:2<41 2007 24 10014 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer