caa a22 4500 463200691 CHVBK 20180405153111.0 cr unu---uuuuu 170326e20071101xx s 000 0 eng 10.1007/s10014-007-0221-5 doi (NATIONALLICENCE)springer-10.1007/s10014-007-0221-5 A rare case of malignant glioma suspected to have arisen from a cavernous sinus [Elektronische Daten] [Katsushi Taomoto, Hideyuki Ohnishi, Yoshitaka Kamada, Yoshihiro Kuga, Norimasa Kohaya, Kazuya Nakashima, Tsugumichi Ichioka, Takashi Tominaga, Mitsutoshi Nakamura, Yoichi Nakazato] A 55-year-old woman presented with a right trigeminal dysfunction (dysesthesia) initially, followed by right oculomotor and abducens paresis lasting 1 month. Neuroimaging studies showed an enhanced mass in the right cavernous sinus extending to the trigeminal ganglion. The extraparenchymal tumor located around the right trigeminal ganglion was totally removed, except for an intracavernous lesion, by the orbitozygomatic approach. The solid tumor was completely separated from the brainstem and seemed to be a trigeminal schwannoma arising from the trigeminal ganglion or cavernous sinus at surgery. A histological examination, however, found a typical malignant glioma that consisted primarily of astrocytic tumor cells. Immunohistochemical staining showed the tumor cells stained intensely for GFAP, S-100 protein, and vimentin, but not for NFP, Schwann/2E, CD34, and CD68. The mean MIB-1 index was 12.4%. The tumor recurred after a short time, and then it rapidly disseminated into the subarachnoid space and left the cerebral hemisphere. The patient died 1 year after the initial symptoms in spite of aggressive surgery, radiation, and chemotherapy with temozolomide. There are no previous reports of a malignant glioma arising from either the cavernous sinus or the trigeminal ganglion. From the pathogenetic point of view, this malignant glioma is an extremely rare case that developed clinically and neuroradiologically from the cavernous sinus and was suspected be being derived from ectopic glial tissue. The Japan Society of Brain Tumor Pathology, 2007 Malignant glioma nationallicence Cavernous sinus nationallicence Trigeminal nerve nationallicence Orbitozygomatic approach nationallicence Chemoradiotherapy nationallicence Taomoto Katsushi Department of Neurosurgery, Ohnishi Neurological Center, 1661-1 Eigashima, Okubo-cho, Akashi, 674-0064, Hyogo, Japan aut Ohnishi Hideyuki Department of Neurosurgery, Ohnishi Neurological Center, 1661-1 Eigashima, Okubo-cho, Akashi, 674-0064, Hyogo, Japan aut Kamada Yoshitaka Department of Neurosurgery, Ohnishi Neurological Center, 1661-1 Eigashima, Okubo-cho, Akashi, 674-0064, Hyogo, Japan aut Kuga Yoshihiro Department of Neurosurgery, Ohnishi Neurological Center, 1661-1 Eigashima, Okubo-cho, Akashi, 674-0064, Hyogo, Japan aut Kohaya Norimasa Department of Neurosurgery, Ohnishi Neurological Center, 1661-1 Eigashima, Okubo-cho, Akashi, 674-0064, Hyogo, Japan aut Nakashima Kazuya Department of Neurosurgery, Ohnishi Neurological Center, 1661-1 Eigashima, Okubo-cho, Akashi, 674-0064, Hyogo, Japan aut Ichioka Tsugumichi Department of Neurosurgery, Ohnishi Neurological Center, 1661-1 Eigashima, Okubo-cho, Akashi, 674-0064, Hyogo, Japan aut Tominaga Takashi Department of Neurosurgery, Ohnishi Neurological Center, 1661-1 Eigashima, Okubo-cho, Akashi, 674-0064, Hyogo, Japan aut Nakamura Mitsutoshi Department of Pathology, Nara Medical University School of Medicine, Nara, Japan aut Nakazato Yoichi Department of Human Pathology, Gunma University Graduate School of Medicine, Gunma, Japan aut Brain Tumor Pathology Springer-Verlag 24/2(2007-11-01), 75-80 1433-7398 24:2<75 2007 24 10014 https://doi.org/10.1007/s10014-007-0221-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10014-007-0221-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Taomoto Katsushi Department of Neurosurgery, Ohnishi Neurological Center, 1661-1 Eigashima, Okubo-cho, Akashi, 674-0064, Hyogo, Japan aut NATIONALLICENCE 700 1- Ohnishi Hideyuki Department of Neurosurgery, Ohnishi Neurological Center, 1661-1 Eigashima, Okubo-cho, Akashi, 674-0064, Hyogo, Japan aut NATIONALLICENCE 700 1- Kamada Yoshitaka Department of Neurosurgery, Ohnishi Neurological Center, 1661-1 Eigashima, Okubo-cho, Akashi, 674-0064, Hyogo, Japan aut NATIONALLICENCE 700 1- Kuga Yoshihiro Department of Neurosurgery, Ohnishi Neurological Center, 1661-1 Eigashima, Okubo-cho, Akashi, 674-0064, Hyogo, Japan aut NATIONALLICENCE 700 1- Kohaya Norimasa Department of Neurosurgery, Ohnishi Neurological Center, 1661-1 Eigashima, Okubo-cho, Akashi, 674-0064, Hyogo, Japan aut NATIONALLICENCE 700 1- Nakashima Kazuya Department of Neurosurgery, Ohnishi Neurological Center, 1661-1 Eigashima, Okubo-cho, Akashi, 674-0064, Hyogo, Japan aut NATIONALLICENCE 700 1- Ichioka Tsugumichi Department of Neurosurgery, Ohnishi Neurological Center, 1661-1 Eigashima, Okubo-cho, Akashi, 674-0064, Hyogo, Japan aut NATIONALLICENCE 700 1- Tominaga Takashi Department of Neurosurgery, Ohnishi Neurological Center, 1661-1 Eigashima, Okubo-cho, Akashi, 674-0064, Hyogo, Japan aut NATIONALLICENCE 700 1- Nakamura Mitsutoshi Department of Pathology, Nara Medical University School of Medicine, Nara, Japan aut NATIONALLICENCE 700 1- Nakazato Yoichi Department of Human Pathology, Gunma University Graduate School of Medicine, Gunma, Japan aut NATIONALLICENCE 773 0- Brain Tumor Pathology Springer-Verlag 24/2(2007-11-01), 75-80 1433-7398 24:2<75 2007 24 10014 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer