caa a22 4500 46320803X CHVBK 20180405153131.0 cr unu---uuuuu 170326e20070201xx s 000 0 eng 10.1007/s10863-006-9055-9 doi (NATIONALLICENCE)springer-10.1007/s10863-006-9055-9 The role of the mitochondria in mediating cytotoxicity of anti-cancer therapies [Elektronische Daten] [Dao Nguyen, Mustafa Hussain] Optimal cytotoxic anticancer therapy, at the cellular level, requires effective and selective induction of cell death to achieve a net reduction of biomass of malignant tissues. Standard cytotoxic chemotherapeutics have been developed based on the observations that mitotically active cancer cells are more susceptible than quiescent normal cells to chromosomal, microtubular or metabolic poisons. More recent development of molecularly targeted drugs for cancer focuses on exploiting biological differentials between normal and transformed cells for selective eradication of cancers. The common thread of "standard” and "novel” cytotoxic drugs is their ability to activate the apoptosis-inducing machinery mediated by mitochondria, also known as the intrinsic death signaling cascade. The aim of this article is to provide an overview of the role of the mitochondria, an energy-generating organelle essential for life, in mediating death when properly activated by cytotoxic stresses. Springer Science+Business Media, LLC, 2007 Mitochondria nationallicence Cancer nationallicence Chemotherapy nationallicence Apo2L/TRAIL nationallicence Bcl2 superfamily nationallicence Apoptosis nationallicence Caspase nationallicence Bax : Bcl2-associated X protein nationallicence Bak : Bcl2-antagonist/killer nationallicence Bcl2 : B cell lymphoma protein 2 nationallicence Bid : Bcl2 inhibitory domain nationallicence Bad : Bcl2 antagonist of cell death nationallicence Bim : Bcl2-interacting mediator of cell death nationallicence Omni/HtrA2 : high temperature requirement protein A2 nationallicence Puma/Bbc3 : p53-upregulated modulator of apoptosis/Bcl2-binding component 3 nationallicence Smac/Diablo : second mitochondria derived activator of caspases/direct inhibitor of apoptosis binding protein with low isoelectric point nationallicence AIF : apoptosis inducing factor nationallicence TRAIL : Tumor necrosis factor related apoptosis inducing ligand nationallicence MOMP : mitochondria outer membrane permeability nationallicence MEK : MAPK kinase nationallicence MAPK : mitogen activated protein kinase nationallicence ERK : extracellular signal regulated kinase nationallicence Apaf-1 : apoptosis-protease activating factor 1 nationallicence JNK : Jun N-terminus kinase nationallicence ANT : adenine nucleotide transporter nationallicence VDAC : voltage-dependent anion channel nationallicence Nguyen Dao Section of Thoracic Oncology, Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Room 4W-4-3940, 10 Center Drive, 29892, Bethesda, MD, USA aut Hussain Mustafa Section of Thoracic Oncology, Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Room 4W-4-3940, 10 Center Drive, 29892, Bethesda, MD, USA aut Journal of Bioenergetics and Biomembranes Kluwer Academic Publishers-Plenum Publishers; http://www.springer-ny.com 39/1(2007-02-01), 13-21 0145-479X 39:1<13 2007 39 10863 https://doi.org/10.1007/s10863-006-9055-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10863-006-9055-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nguyen Dao Section of Thoracic Oncology, Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Room 4W-4-3940, 10 Center Drive, 29892, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Hussain Mustafa Section of Thoracic Oncology, Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Room 4W-4-3940, 10 Center Drive, 29892, Bethesda, MD, USA aut NATIONALLICENCE 773 0- Journal of Bioenergetics and Biomembranes Kluwer Academic Publishers-Plenum Publishers; http://www.springer-ny.com 39/1(2007-02-01), 13-21 0145-479X 39:1<13 2007 39 10863 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer