caa a22 4500 463208048 CHVBK 20180405153131.0 cr unu---uuuuu 170326e20070201xx s 000 0 eng 10.1007/s10863-006-9061-y doi (NATIONALLICENCE)springer-10.1007/s10863-006-9061-y Mitochondria-mediated ATP depletion by anti-cancer agents of the jasmonate family [Elektronische Daten] [Natalia Goldin, Alina Heyfets, Dorit Reischer, Eliezer Flescher] Jasmonates are plant stress hormones that induce suppression of proliferation and death in cancer cells, while being selectively inactive towards non-transformed cells. Jasmonates can overcome apoptotic blocks and exert cytotoxic effects on drug-resistant cells expressing p53 mutations. Jasmonates induce a rapid depletion of ATP in cancer cells. Indeed, this steep drop occurs when no signs of cell death are detectable yet. Experiments using modulators of ATP synthesis via glycolysis or oxidative phosphorylation suggest that the latter is the pathway suppressed by jasmonates. Consequently, the direct effects of jasmonates on mitochondria were evaluated. Jasmonates induced cytochrome c release and swelling in mitochondria isolated from cancer cells but not from normal ones. Thus, the selectivity of jasmonates against cancer cells is rooted at the mitochondrial level, and probably exploits differences between mitochondria from normal versus cancer cells. These findings position jasmonates as promising anti-cancer drugs acting via energetic depletion in neoplastic cells. Springer Science+Business Media, LLC, 2007 Cancer nationallicence Jasmonate nationallicence Plant nationallicence Energy nationallicence Glycolysis nationallicence Goldin Natalia Department of Human Microbiology, Sackler Faculty of Medicine, Tel Aviv University, 69978, Tel Aviv, Israel aut Heyfets Alina Department of Human Microbiology, Sackler Faculty of Medicine, Tel Aviv University, 69978, Tel Aviv, Israel aut Reischer Dorit Department of Human Microbiology, Sackler Faculty of Medicine, Tel Aviv University, 69978, Tel Aviv, Israel aut Flescher Eliezer Department of Human Microbiology, Sackler Faculty of Medicine, Tel Aviv University, 69978, Tel Aviv, Israel aut Journal of Bioenergetics and Biomembranes Kluwer Academic Publishers-Plenum Publishers; http://www.springer-ny.com 39/1(2007-02-01), 51-57 0145-479X 39:1<51 2007 39 10863 https://doi.org/10.1007/s10863-006-9061-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10863-006-9061-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Goldin Natalia Department of Human Microbiology, Sackler Faculty of Medicine, Tel Aviv University, 69978, Tel Aviv, Israel aut NATIONALLICENCE 700 1- Heyfets Alina Department of Human Microbiology, Sackler Faculty of Medicine, Tel Aviv University, 69978, Tel Aviv, Israel aut NATIONALLICENCE 700 1- Reischer Dorit Department of Human Microbiology, Sackler Faculty of Medicine, Tel Aviv University, 69978, Tel Aviv, Israel aut NATIONALLICENCE 700 1- Flescher Eliezer Department of Human Microbiology, Sackler Faculty of Medicine, Tel Aviv University, 69978, Tel Aviv, Israel aut NATIONALLICENCE 773 0- Journal of Bioenergetics and Biomembranes Kluwer Academic Publishers-Plenum Publishers; http://www.springer-ny.com 39/1(2007-02-01), 51-57 0145-479X 39:1<51 2007 39 10863 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer