caa a22 4500 463208080 CHVBK 20180405153131.0 cr unu---uuuuu 170326e20070201xx s 000 0 eng 10.1007/s10863-006-9053-y doi (NATIONALLICENCE)springer-10.1007/s10863-006-9053-y Resveratrol in cell fate decisions [Elektronische Daten] [Andrea Holme, Shazib Pervaiz] Resveratrol, a polyphenolic phytoalexin, is one of the most extensively studied natural products, with wide ranging biological activity and tremendous clinical potential. First identified from fruits and plants, in particular grapes and wines, its positive effects on a variety of disease states have been unraveled over the past decade or so. Most noticeable are its anti-thrombogenic, anti-inflammatory, cardio-protective, neuro-protective, anti-aging, and cancer preventive and therapeutic activities. Recent data also indicate that depending upon the concentration/dose, resveratrol can trigger or block cell death signaling in tumor cells. Considering the heightened interest in this compound, here we present a short review on the biological activity of this remarkable compound, with a specific focus on its effects on cell survival and death signals. Springer Science+Business Media, LLC, 2007 Resveratrol nationallicence Mitochondria nationallicence Apoptosis nationallicence ROS nationallicence Holme Andrea ROS Biology and Apoptosis Group, National University Medical Institutes, National University of Singapore, 117597, Singapore, Singapore aut Pervaiz Shazib Department of Physiology, Yong Loo Lin School of Medicine, and NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, 2 Medical Drive, MD9 #03-06, 117597, Singapore, Singapore aut Journal of Bioenergetics and Biomembranes Kluwer Academic Publishers-Plenum Publishers; http://www.springer-ny.com 39/1(2007-02-01), 59-63 0145-479X 39:1<59 2007 39 10863 https://doi.org/10.1007/s10863-006-9053-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10863-006-9053-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Holme Andrea ROS Biology and Apoptosis Group, National University Medical Institutes, National University of Singapore, 117597, Singapore, Singapore aut NATIONALLICENCE 700 1- Pervaiz Shazib Department of Physiology, Yong Loo Lin School of Medicine, and NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, 2 Medical Drive, MD9 #03-06, 117597, Singapore, Singapore aut NATIONALLICENCE 773 0- Journal of Bioenergetics and Biomembranes Kluwer Academic Publishers-Plenum Publishers; http://www.springer-ny.com 39/1(2007-02-01), 59-63 0145-479X 39:1<59 2007 39 10863 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer