caa a22 4500 463208099 CHVBK 20180405153132.0 cr unu---uuuuu 170326e20070201xx s 000 0 eng 10.1007/s10863-006-9054-x doi (NATIONALLICENCE)springer-10.1007/s10863-006-9054-x Alteration of mitochondrial function and cell sensitization to death [Elektronische Daten] [Vladimir Gogvadze, Boris Zhivotovsky] Stimulation of cell death is a powerful instrument in the organism's struggle with cancer. Apoptosis represents one mode of cell death. However, in a variety of tumor cells proapoptotic mechanisms are downregulated, or not properly activated, whereas antiapoptotic mechanisms are upregulated. Mitochondria are known as key players in the regulation of apoptotic pathways. Specifically, permeabilization of the mitochondrial outer membrane and subsequent release of proapoptotic proteins from the intermembrane space are viewed as decisive events in the initiation and/or execution of apoptosis. Disruption of mitochondrial functions by anticancer drugs, which induce oxidative stress, inhibit mitochondrial respiration, or uncouple oxidative phosphorylation, can sensitize mitochondria in these cells and facilitate outer membrane permeabilization. Springer Science+Business Media, LLC, 2007 Mitochondria nationallicence Apoptosis nationallicence Permeability transition nationallicence Cytochrome c nationallicence Cardiolipin nationallicence Gogvadze Vladimir Institute of Environmental Medicine, Division of Toxicology, Karolinska Institutet, Box 210, SE-171 77, Stockholm, Sweden aut Zhivotovsky Boris Institute of Environmental Medicine, Division of Toxicology, Karolinska Institutet, Box 210, SE-171 77, Stockholm, Sweden aut Journal of Bioenergetics and Biomembranes Kluwer Academic Publishers-Plenum Publishers; http://www.springer-ny.com 39/1(2007-02-01), 23-30 0145-479X 39:1<23 2007 39 10863 https://doi.org/10.1007/s10863-006-9054-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10863-006-9054-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gogvadze Vladimir Institute of Environmental Medicine, Division of Toxicology, Karolinska Institutet, Box 210, SE-171 77, Stockholm, Sweden aut NATIONALLICENCE 700 1- Zhivotovsky Boris Institute of Environmental Medicine, Division of Toxicology, Karolinska Institutet, Box 210, SE-171 77, Stockholm, Sweden aut NATIONALLICENCE 773 0- Journal of Bioenergetics and Biomembranes Kluwer Academic Publishers-Plenum Publishers; http://www.springer-ny.com 39/1(2007-02-01), 23-30 0145-479X 39:1<23 2007 39 10863 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer