caa a22 4500 463208153 CHVBK 20180405153132.0 cr unu---uuuuu 170326e20070201xx s 000 0 eng 10.1007/s10863-006-9056-8 doi (NATIONALLICENCE)springer-10.1007/s10863-006-9056-8 Chemotherapy through mitochondrial apoptosis using nutritional supplements and herbs: A brief overview [Elektronische Daten] [Kang-Beom Kwon, Byung-Hyun Park, Do-Gon Ryu] There has been increased interest in the use of naturally occurring compounds with chemopreventive and chemotherapeutic effects in the treatment of cancers. This review summarizes the most recent advances that provide new insights into the molecular mechanisms underlying the apoptotic potential of nutritional supplements and herbs. Apoptosis is an essential process in the pathogenesis of cancer and its mechanisms can be subdivided into either a death receptor-dependent extrinsic pathway or an independent (mitochondrial or intrinsic) pathway. Nutritional supplements and herbs can exert their effects on such pathways separately, sequentially, or in a manner of "crosstalk” between pathways. A strong correlation between the early collapse of the mitochondrial membrane potential and apoptosis was found for most nutritional supplements and herbs that have been studied. These observations provide examples of the development of mitochondrial targeting strategies for cancer therapy. Springer Science+Business Media, LLC, 2007 Mitochondria nationallicence Apoptosis nationallicence Herb nationallicence Nutritional supplement nationallicence Kwon Kang-Beom Department of Physiology, School of Oriental Medicine, Wonkwang University, 570-749, Iksan, Jeonbuk, Korea aut Park Byung-Hyun Department of Biochemistry, Medical School, and Institute for Healthcare Technology Development, Chonbuk National University, 561-756, Jeonju, Jeonbuk, Korea aut Ryu Do-Gon Department of Physiology, School of Oriental Medicine, Wonkwang University, 570-749, Iksan, Jeonbuk, Korea aut Journal of Bioenergetics and Biomembranes Kluwer Academic Publishers-Plenum Publishers; http://www.springer-ny.com 39/1(2007-02-01), 31-34 0145-479X 39:1<31 2007 39 10863 https://doi.org/10.1007/s10863-006-9056-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10863-006-9056-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kwon Kang-Beom Department of Physiology, School of Oriental Medicine, Wonkwang University, 570-749, Iksan, Jeonbuk, Korea aut NATIONALLICENCE 700 1- Park Byung-Hyun Department of Biochemistry, Medical School, and Institute for Healthcare Technology Development, Chonbuk National University, 561-756, Jeonju, Jeonbuk, Korea aut NATIONALLICENCE 700 1- Ryu Do-Gon Department of Physiology, School of Oriental Medicine, Wonkwang University, 570-749, Iksan, Jeonbuk, Korea aut NATIONALLICENCE 773 0- Journal of Bioenergetics and Biomembranes Kluwer Academic Publishers-Plenum Publishers; http://www.springer-ny.com 39/1(2007-02-01), 31-34 0145-479X 39:1<31 2007 39 10863 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer