caa a22 4500 463208161 CHVBK 20180405153132.0 cr unu---uuuuu 170326e20070201xx s 000 0 eng 10.1007/s10863-006-9059-5 doi (NATIONALLICENCE)springer-10.1007/s10863-006-9059-5 Mitochondria as a critical target of the chemotheraputic agent cisplatin in head and neck cancer [Elektronische Daten] [Kevin Cullen, Zejia Yang, Lisa Schumaker, Zhongmin Guo] Cisplatin is among the most important chemotherapeutic agents ever developed. It is a critical component of therapeutic regimens in a broad range of malignancies. However, more than a generation after its clinical introduction, the exact mechanism of cisplatin action on tumor cells is not fully defined. The preponderance of research over the last three decades has focused on cisplatin interactions with nuclear DNA which are felt to lead to apoptotic cell death in sensitive cells. However, recent data have shown that cisplatin may have important direct interactions with mitochondria which can induce apoptosis and may account for a significant portion of the clinical activity associated with this drug. These direct interactions between cisplatin and mitochondria may have critical implications for our understanding of this class of drugs and the development of new therapeutic agents. Springer Science+Business Media, LLC, 2007 cisplatin nationallicence mitochondria nationallicence head and neck cancer nationallicence DNA nationallicence voltage dependent anion channel nationallicence Cullen Kevin University of Maryland Marlene and Stewart Greenebaum Cancer Center, Baltimore, MD, USA aut Yang Zejia University of Maryland Marlene and Stewart Greenebaum Cancer Center, Baltimore, MD, USA aut Schumaker Lisa University of Maryland Marlene and Stewart Greenebaum Cancer Center, Baltimore, MD, USA aut Guo Zhongmin University of Maryland Marlene and Stewart Greenebaum Cancer Center, Baltimore, MD, USA aut Journal of Bioenergetics and Biomembranes Kluwer Academic Publishers-Plenum Publishers; http://www.springer-ny.com 39/1(2007-02-01), 43-50 0145-479X 39:1<43 2007 39 10863 https://doi.org/10.1007/s10863-006-9059-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10863-006-9059-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cullen Kevin University of Maryland Marlene and Stewart Greenebaum Cancer Center, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Yang Zejia University of Maryland Marlene and Stewart Greenebaum Cancer Center, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Schumaker Lisa University of Maryland Marlene and Stewart Greenebaum Cancer Center, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Guo Zhongmin University of Maryland Marlene and Stewart Greenebaum Cancer Center, Baltimore, MD, USA aut NATIONALLICENCE 773 0- Journal of Bioenergetics and Biomembranes Kluwer Academic Publishers-Plenum Publishers; http://www.springer-ny.com 39/1(2007-02-01), 43-50 0145-479X 39:1<43 2007 39 10863 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer