caa a22 4500 46320817X CHVBK 20180405153132.0 cr unu---uuuuu 170326e20070201xx s 000 0 eng 10.1007/s10863-006-9063-9 doi (NATIONALLICENCE)springer-10.1007/s10863-006-9063-9 Galectin-3 in apoptosis, a novel therapeutic target [Elektronische Daten] [Pratima Nangia-Makker, Susumu Nakahara, Victor Hogan, Avraham Raz] During the past decade, extensive progress has been made toward understanding the molecular basis for the regulation of apoptosis. In mammalian cells undergoing apoptosis, two distinct mechanisms or pathways are operated and are triggered by cell death stimuli from intra- or extra-cellular environments, namely the intrinsic or extrinsic pathways, resulting in mitochondrial membrane depolarization. Several lines of evidence from our laboratories and others have indicated that galectin-3 plays an important role in these pathways by binding to various ligands. Here the authors provide a brief discussion on the role of endogenous or extra-cellular galectin-3 in the regulation of apoptosis and how it could be used as a therapeutic target using natural plant products as its functional inhibitors. Springer Science+Business Media, LLC, 2007 Extrinsic apoptotic pathways nationallicence Intrinsic apoptotic pathways nationallicence Galectin-3 nationallicence Modified citrus pectin nationallicence Nangia-Makker Pratima Department of Pathology, Karmanos Cancer Institute, Wayne State University, 110 East Warren Avenue, 48201, Detroit, MI, USA aut Nakahara Susumu Department of Pathology, Karmanos Cancer Institute, Wayne State University, 110 East Warren Avenue, 48201, Detroit, MI, USA aut Hogan Victor Department of Pathology, Karmanos Cancer Institute, Wayne State University, 110 East Warren Avenue, 48201, Detroit, MI, USA aut Raz Avraham Department of Pathology, Karmanos Cancer Institute, Wayne State University, 110 East Warren Avenue, 48201, Detroit, MI, USA aut Journal of Bioenergetics and Biomembranes Kluwer Academic Publishers-Plenum Publishers; http://www.springer-ny.com 39/1(2007-02-01), 79-84 0145-479X 39:1<79 2007 39 10863 https://doi.org/10.1007/s10863-006-9063-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10863-006-9063-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nangia-Makker Pratima Department of Pathology, Karmanos Cancer Institute, Wayne State University, 110 East Warren Avenue, 48201, Detroit, MI, USA aut NATIONALLICENCE 700 1- Nakahara Susumu Department of Pathology, Karmanos Cancer Institute, Wayne State University, 110 East Warren Avenue, 48201, Detroit, MI, USA aut NATIONALLICENCE 700 1- Hogan Victor Department of Pathology, Karmanos Cancer Institute, Wayne State University, 110 East Warren Avenue, 48201, Detroit, MI, USA aut NATIONALLICENCE 700 1- Raz Avraham Department of Pathology, Karmanos Cancer Institute, Wayne State University, 110 East Warren Avenue, 48201, Detroit, MI, USA aut NATIONALLICENCE 773 0- Journal of Bioenergetics and Biomembranes Kluwer Academic Publishers-Plenum Publishers; http://www.springer-ny.com 39/1(2007-02-01), 79-84 0145-479X 39:1<79 2007 39 10863 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer