caa a22 4500 46320820X CHVBK 20180405153132.0 cr unu---uuuuu 170326e20070601xx s 000 0 eng 10.1007/s10863-007-9083-0 doi (NATIONALLICENCE)springer-10.1007/s10863-007-9083-0 A pivotal role for p53: balancing aerobic respiration and glycolysis [Elektronische Daten] [Wenzhe Ma, Ho Sung, Joon Park, Satoaki Matoba, Paul Hwang] The genetic basis of increased glycolytic activity observed in cancer cells is likely to be the result of complex interactions of multiple regulatory pathways. Here we review the recent evidence of a simple genetic mechanism by which tumor suppressor p53 regulates mitochondrial respiration with secondary changes in glycolysis that are reminiscent of the Warburg effect. The biological significance of this regulation of the two major pathways of energy generation by p53 remains to be seen. Springer Science+Business Media, LLC, 2007 Synthesis of cytochrome c oxidase 2 nationallicence Cytochrome c oxidase nationallicence Tumor protein p53 nationallicence Ma Wenzhe Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, 10-CRC/5-5330, 20892, Bethesda, MD, USA aut Sung Ho Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, 10-CRC/5-5330, 20892, Bethesda, MD, USA aut Park Joon Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, 10-CRC/5-5330, 20892, Bethesda, MD, USA aut Matoba Satoaki Department of Cardiovascular Medicine, Kyoto Prefectural University of Medicine, 602-8566, Kyoto, Japan aut Hwang Paul Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, 10-CRC/5-5330, 20892, Bethesda, MD, USA aut Journal of Bioenergetics and Biomembranes Springer US; http://www.springer-ny.com 39/3(2007-06-01), 243-246 0145-479X 39:3<243 2007 39 10863 https://doi.org/10.1007/s10863-007-9083-0 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10863-007-9083-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ma Wenzhe Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, 10-CRC/5-5330, 20892, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Sung Ho Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, 10-CRC/5-5330, 20892, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Park Joon Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, 10-CRC/5-5330, 20892, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Matoba Satoaki Department of Cardiovascular Medicine, Kyoto Prefectural University of Medicine, 602-8566, Kyoto, Japan aut NATIONALLICENCE 700 1- Hwang Paul Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, 10-CRC/5-5330, 20892, Bethesda, MD, USA aut NATIONALLICENCE 773 0- Journal of Bioenergetics and Biomembranes Springer US; http://www.springer-ny.com 39/3(2007-06-01), 243-246 0145-479X 39:3<243 2007 39 10863 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer