caa a22 4500 463208218 CHVBK 20180405153132.0 cr unu---uuuuu 170326e20070601xx s 000 0 eng 10.1007/s10863-007-9086-x doi (NATIONALLICENCE)springer-10.1007/s10863-007-9086-x The Warburg effect and its cancer therapeutic implications [Elektronische Daten] [Zhao Chen, Weiqin Lu, Celia Garcia-Prieto, Peng Huang] Increased aerobic glycolysis in cancer, a phenomenon known as the Warburg effect, has been observed in various tumor cells and represents a major biochemical alteration associated with malignant transformation. Although the exact molecular mechanisms underlying this metabolic change remain to be elucidated, the profound biochemical alteration in cancer cell energy metabolism provides exciting opportunities for the development of therapeutic strategies to preferentially kill cancer cells by targeting the glycolytic pathway. Several small molecules capable of inhibiting glycolysis in experimental systems have been shown to have promising anticancer activity in vitro and in vivo. This review article provides a brief summary of our current understanding of the Warburg effect, the underlying mechanisms, and its influence on the development of therapeutic strategies for cancer treatment. Springer Science+Business Media, LLC, 2007 Warburg effect nationallicence Glycolysis nationallicence Inhibitor nationallicence Mitochondria nationallicence Cancer therapeutics nationallicence Drug resistance nationallicence Reactive oxygen species (ROS) nationallicence Oncogene nationallicence Hypoxia nationallicence Chen Zhao Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, 7435 Fannin Street, 77030, Houston, TX, USA aut Lu Weiqin Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, 7435 Fannin Street, 77030, Houston, TX, USA aut Garcia-Prieto Celia Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, 7435 Fannin Street, 77030, Houston, TX, USA aut Huang Peng Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, 7435 Fannin Street, 77030, Houston, TX, USA aut Journal of Bioenergetics and Biomembranes Springer US; http://www.springer-ny.com 39/3(2007-06-01), 267-274 0145-479X 39:3<267 2007 39 10863 https://doi.org/10.1007/s10863-007-9086-x text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10863-007-9086-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chen Zhao Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, 7435 Fannin Street, 77030, Houston, TX, USA aut NATIONALLICENCE 700 1- Lu Weiqin Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, 7435 Fannin Street, 77030, Houston, TX, USA aut NATIONALLICENCE 700 1- Garcia-Prieto Celia Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, 7435 Fannin Street, 77030, Houston, TX, USA aut NATIONALLICENCE 700 1- Huang Peng Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, 7435 Fannin Street, 77030, Houston, TX, USA aut NATIONALLICENCE 773 0- Journal of Bioenergetics and Biomembranes Springer US; http://www.springer-ny.com 39/3(2007-06-01), 267-274 0145-479X 39:3<267 2007 39 10863 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer